GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Several common variants modulate heart rate, PR interval and QRS duration.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
cav1 CAV1 ENSDARG00000052004 None Not determined 5
cdkn1a CDKN1A ENSDARG00000076554 None Not determined 4
cdkn1c CDKN1A ENSDARG00000010878 1 Not determined 4
dkk1a DKK1 ENSDARG00000014103 None Not determined 2
dkk1b DKK1 ENSDARG00000045219 5 Not determined 2
KCNE1 KCNE1 ENSDARG00000087204 1 Not determined 1
kcnh2 KCNH2 ENSDARG00000029881 7 Not determined 5
kcnq1 KCNQ1 ENSDARG00000059798 4 Not determined 15
KCNQ1 KCNQ1 ENSDARG00000091599 None Not determined 15
LOC100001366 MYH6 ENSDARG00000093715 3 Not determined 3
LOC100004175 CDKN1A ENSDARG00000089854 None Not determined 4
LOC100150282 KCNH2 ENSDARG00000060053 None Not determined 5
LOC100329748 MYH6 ENSDARG00000093148 None Not determined 3
LOC100329813 MYH6 ENSDARG00000092902 3 Not determined 3
myh6 MYH6 ENSDARG00000090637 6 Not determined 3
myha MYH6 ENSDARG00000071435 4 Not determined 3
myhb MYH6 ENSDARG00000001993 4 Not determined 3
myhc4 MYH6 ENSDARG00000035438 6 Not determined 3
myhz1.1 MYH6 ENSDARG00000067990 2 Not determined 3
myhz1.2 MYH6 ENSDARG00000067995 8 Not determined 3
myhz1.3 MYH6 ENSDARG00000067997 4 Not determined 3
myhz2 MYH6 ENSDARG00000012944 8 Not determined 3
ndrg4 NDRG4 ENSDARG00000062236 1 Not determined 4
nos1apa NOS1AP ENSDARG00000078725 None Not determined 10
NP_001038387.1 SCN5A ENSDARG00000059692 6 Not determined 9
NP_001038387.1 SCN10A ENSDARG00000059692 6 Not determined 8
Q5SPS0_DANRE C6orf204 ENSDARG00000093883 2 Not determined 5
si:ch211-112m17.3 C6orf204 ENSDARG00000020777 3 Not determined 5
si:ch211-158m24.10 MYH6 ENSDARG00000090103 7 Not determined 3
si:ch211-247j9.1 ARHGAP24 ENSDARG00000079283 1 Not determined 4
si:ch211-65i12.2 ARHGAP24 ENSDARG00000060175 5 Not determined 4
si:dkey-34e4.1 NOS1AP ENSDARG00000022085 1 Not determined 10
smyhc1 MYH6 ENSDARG00000071430 7 Not determined 3
smyhc2 MYH6 ENSDARG00000071433 6 Not determined 3
smyhc3 MYH6 ENSDARG00000045242 1 Not determined 3
tbx5a TBX5 ENSDARG00000024894 None Not determined 10
tbx5b TBX5 ENSDARG00000092060 None Not determined 10
vmhc MYH6 ENSDARG00000079564 20 Not determined 3
vmhcl MYH6 ENSDARG00000079782 7 Not determined 3
wu:fd14a01 MYH6 ENSDARG00000035437 3 Not determined 3
zgc:66156 MYH6 ENSDARG00000053207 1 Not determined 3
zgc:66156 MYH6 ENSDARG00000093467 None Not determined 3
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