GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
cdkal1 CDKAL1 ENSDARG00000022122 2 Not determined 23
cetn3 CETN3 ENSDARG00000011825 None Not determined 1
im:7150991 WFS1 ENSDARG00000074617 5 Not determined 2
LOC100002134 SLC30A8 ENSDARG00000054584 1 Not determined 16
LOC559281 IRS1 ENSDARG00000054087 2 Not determined 7
LOC559392 PPP2R2C ENSDARG00000062277 2 Not determined 1
LOC560642 SLC30A8 ENSDARG00000057629 None Not determined 16
ppp2r2c PPP2R2C ENSDARG00000056797 1 Not determined 1
tcf7l2 TCF7L2 ENSDARG00000004415 5 Not determined 23
WFS1 (1 of 2) WFS1 ENSDARG00000062341 3 Not determined 2
zgc:56306 IRS1 ENSDARG00000037099 1 Not determined 7

The following reported genes could not be linked automatically to a zebrafish gene:

  • LOC64673
  • LOC72901
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