GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
cxcr4a CXCR4 ENSDARG00000057633 1 Not determined 2
cxcr4b CXCR4 ENSDARG00000041959 None Not determined 2
il7r IL7R ENSDARG00000078970 None Not determined 7
irf8 IRF8 ENSDARG00000056407 None Not determined 9
LOC100332780 ZMIZ1 ENSDARG00000076477 3 Not determined 10
mhc2dab HLA-DRB1 ENSDARG00000079105 None Not determined 35
MPHOSPH9 MPHOSPH9 ENSDARG00000079091 None Not determined 1
NP_001091732.1 HLA-DRB1 ENSDARG00000071168 1 Not determined 35
ptger4a PTGER4 ENSDARG00000059236 2 Normal 12
ptger4b PTGER4 ENSDARG00000035415 1 Not determined 12
si:busm1-104n07.3 HLA-DRB1 ENSDARG00000074510 1 Normal 35
si:busm1-160c18.3 HLA-DRB1 ENSDARG00000053738 None Not determined 35
si:busm1-160c18.3 HLA-DRB1 ENSDARG00000093706 None Not determined 35
si:busm1-194e12.12 HLA-DRB1 ENSDARG00000055447 None Not determined 35
si:busm1-228j01.4 HLA-DRB1 ENSDARG00000088872 2 Not determined 35
si:busm1-228j01.6 HLA-DRB1 ENSDARG00000041705 1 Not determined 35
si:ch211-234e14.2 PTGER4 ENSDARG00000079907 None Not determined 12
si:dkey-8e10.2 CD6 ENSDARG00000069542 4 Not determined 4
si:zfos-2070c2.3 HLA-DRB1 ENSDARG00000076307 None Not determined 35
tnfrsf1a TNFRSF1A ENSDARG00000018569 2 Not determined 3
TNFRSF1A (1 of 2) TNFRSF1A ENSDARG00000090478 None Not determined 3
wu:fd58b11 HLA-DRB1 ENSDARG00000054921 None Not determined 35
zgc:153067 HLA-DRB1 ENSDARG00000056330 2 Not determined 35
zgc:56230 CLEC16A ENSDARG00000038094 3 Not determined 13
zmiz1 ZMIZ1 ENSDARG00000074502 10 Not determined 10

The following reported genes could not be linked automatically to a zebrafish gene:

  • CD58
  • HLA-B
  • IL12A
  • IL2RA
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