GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
atg16l1 ATG16L1 ENSDARG00000057430 None Not determined 8
ccr6a CCR6 ENSDARG00000087474 4 Not determined 7
ccr6b CCR6 ENSDARG00000038968 2 Not determined 7
cdkal1 CDKAL1 ENSDARG00000022122 2 Not determined 23
il12ba IL12B ENSDARG00000033727 2 Not determined 14
irgf1 IRGM ENSDARG00000070774 3 Not determined 5
irgf2 IRGM ENSDARG00000092249 1 Not determined 5
irgf3 IRGM ENSDARG00000062820 None Not determined 5
irgq2 IRGM ENSDARG00000068657 None Not determined 5
itln1 ITLN1 ENSDARG00000007534 None Not determined 3
itln2 ITLN1 ENSDARG00000036084 None Not determined 3
itln2 ITLN1 ENSDARG00000093796 1 Not determined 3
itln3 ITLN1 ENSDARG00000003523 3 Not determined 3
itln4 ITLN1 ENSDARG00000053630 2 Normal 3
jak2a JAK2 ENSDARG00000007915 2 Not determined 8
jak2b JAK2 ENSDARG00000018882 5 Not determined 8
LOC100001799 IL12B ENSDARG00000069504 1 Not determined 14
LOC100329651 MUC19 ENSDARG00000057436 1 Not determined 3
LOC564958 ITLN1 ENSDARG00000095082 1 Not determined 3
LOC565124 ITLN1 ENSDARG00000036085 None Not determined 3
LOC799320 ZNF365 ENSDARG00000087985 1 Not determined 11
LRRK2 LRRK2 ENSDARG00000006169 6 Not determined 8
nkx2.3 NKX2-3 ENSDARG00000039095 None Not determined 10
nkx2.7 NKX2-3 ENSDARG00000021232 1 1 phenotype 10
nod2 NOD2 ENSDARG00000010756 3 Not determined 10
NP_694512.1 MST1 ENSDARG00000031855 2 Not determined 9
ptger4a PTGER4 ENSDARG00000059236 2 Normal 12
ptger4b PTGER4 ENSDARG00000035415 1 Not determined 12
ptpn22 PTPN22 ENSDARG00000075062 5 Not determined 17
ptpn2a PTPN2 ENSDARG00000016481 4 Not determined 13
ptpn2b PTPN2 ENSDARG00000035986 2 Not determined 13
si:ch211-213n8.3 IL12B ENSDARG00000054542 1 Not determined 14
si:ch211-234e14.2 PTGER4 ENSDARG00000079907 None Not determined 12
si:ch73-233m11.2 NOD2 ENSDARG00000091859 None Not determined 10
stat3 STAT3 ENSDARG00000022712 5 Not determined 7
zgc:101654 ORMDL3 ENSDARG00000025555 1 Not determined 14
zgc:153219 ITLN1 ENSDARG00000054054 2 Not determined 3
zgc:56039 C11orf30 ENSDARG00000059059 1 Not determined 5

The following reported genes could not be linked automatically to a zebrafish gene:

  • ICOSLG
  • IL23R
  • TNFSF15
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