si:ch73-233m11.2

Ensembl ID:
ENSDARG00000091859
ZFIN ID:
ZDB-GENE-081104-266
Description:
Novel protein containing Leucine Rich Repeat (LRR_1) domains [Source:UniProtKB/TrEMBL;Acc:B0V3S0]
Human Orthologues:
CIITA, NLRC5, NOD1, NOD2
Human Descriptions:
class II, major histocompatibility complex, transactivator [Source:HGNC Symbol;Acc:7067]
NLR family, CARD domain containing 5 [Source:HGNC Symbol;Acc:29933]
nucleotide-binding oligomerization domain containing 1 [Source:HGNC Symbol;Acc:16390]
nucleotide-binding oligomerization domain containing 2 [Source:HGNC Symbol;Acc:5331]
Mouse Orthologues:
Ciita, Nod1, Nod2
Mouse Descriptions:
class II transactivator Gene [Source:MGI Symbol;Acc:MGI:108445]
nucleotide-binding oligomerization domain containing 1 Gene [Source:MGI Symbol;Acc:MGI:1341839]
nucleotide-binding oligomerization domain containing 2 Gene [Source:MGI Symbol;Acc:MGI:2429397]

Alleles

No alleles have been identified for ENSDARG00000091859 yet.

GWAS

This gene's human homologue has been identified in the following GWAS studies:

  • Celiac disease: Multiple common variants for celiac disease influencing immune gene expression. (View Study)
  • Crohn's disease: A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300. (View Study)
  • Crohn's disease: A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (View Study)
  • Crohn's disease: Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease. (View Study)
  • Crohn's disease: Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. (View Study)
  • Crohn's disease: Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci. (View Study)
  • Crohn's disease: Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (View Study)
  • Inflammatory bowel disease: Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. (View Study)
  • Leprosy: Genomewide association study of leprosy. (View Study)
  • Schizophrenia: Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder. (View Study)
  • Schizophrenia: Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms. (View Study)
  • Type 2 diabetes: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. (View Study)
  • Ulcerative colitis: Genome-wide association identifies multiple ulcerative colitis susceptibility loci. (View Study)
  • Ulcerative colitis: Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (View Study)

(GWAS data comes from http://www.genome.gov/gwastudies/.)

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