xrn1

Ensembl ID:
ENSDARG00000091652
ZFIN IDs:
ZDB-GENE-040426-1203, ZDB-GENE-040426-1203
Description:
5'-3' exoribonuclease 1 [Source:RefSeq peptide;Acc:NP_957327]
Human Orthologue:
XRN1
Human Description:
5'-3' exoribonuclease 1 [Source:HGNC Symbol;Acc:30654]
Mouse Orthologue:
Xrn1
Mouse Description:
5'-3' exoribonuclease 1 Gene [Source:MGI Symbol;Acc:MGI:891964]

Alleles

There are 11 alleles of this gene:

Allele name Consequence Status Availability Estimate
sa31269 Nonsense Available for shipment Available now
sa19713 Nonsense Available for shipment Available now
sa19714 Nonsense Available for shipment Available now
sa32872 Essential Splice Site Mutation detected in F1 DNA During 2018
sa32873 Essential Splice Site Mutation detected in F1 DNA During 2018
sa6008 Nonsense Mutation detected in F1 DNA During 2018
sa32874 Essential Splice Site Available for shipment Available now
sa45094 Nonsense Mutation detected in F1 DNA During 2018
sa39802 Nonsense Mutation detected in F1 DNA During 2018
sa19715 Nonsense Available for shipment Available now
sa19716 Essential Splice Site Available for shipment Available now

Mutation Details

Allele Name:
sa31269
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
T > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000121772   None 504 1 18
ENSDART00000125413 Nonsense 7 1697 1 42
Genomic Location (Zv9):
Chromosome 2 (position 16417717)
Other Location(s):
Assembly Chromosome Position
GRCz10 2 16928544
GRCz11 2 16597134
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
CTATTTTTATTTGAAGACTTACACGAGACGATGGGAGTGCCTAAGTTTTA[T/A]CGATGGATATCAGAGCGGTATCCGTGTCTGAGTGAAGTTGTCAAAGAGCA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa19713
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
T > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000121772   None 504 None 18
ENSDART00000125413 Nonsense 67 1697 2 42
Genomic Location (Zv9):
Chromosome 2 (position 16420327)
Other Location(s):
Assembly Chromosome Position
GRCz10 2 16931154
GRCz11 2 16599744
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
GTGCACTTCCGTATTTCTGAAGAGAAGATATTCGCTGACATTTTTCACTA[T/A]CTGGAAGTGCTCTTTCGCATCATTAAGCCAAGGAAAGTGTTCTTCATGGC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa19714
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
C > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000121772 Nonsense 38 504 4 18
ENSDART00000125413 Nonsense 127 1697 3 42
Genomic Location (Zv9):
Chromosome 2 (position 16421250)
Other Location(s):
Assembly Chromosome Position
GRCz10 2 16932077
GRCz11 2 16600667
KASP Assay ID:
2259-1799.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
AGAAAATCAAGAAGGCCTTGGAGAAGGGAGAAGTTTTGCCCACAGAGGCC[C/T]GATTTGACTCTAACTGCATCACTCCGGGTTTGTGTTCATTTATCGCTTAC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa32872
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2018.
Mutation:
T > A
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000121772   None 504 None 18
ENSDART00000125413 Essential Splice Site 779 1697 20 42
Genomic Location (Zv9):
Chromosome 2 (position 16444259)
Other Location(s):
Assembly Chromosome Position
GRCz10 2 16955086
GRCz11 2 16623676
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
ATAAAGAGCAGAAGGACTGGGTCAAAGAAGTGCAAGGCCTCACAGAGCAG[T/A]AAGCTGAAACCTTTATTAACTTTATTTATTCACGTAATTTATTAACAAGA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa32873
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2018.
Mutation:
T > G
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000121772   None 504 None 18
ENSDART00000125413 Essential Splice Site 833 1697 21 42
Genomic Location (Zv9):
Chromosome 2 (position 16446454)
Other Location(s):
Assembly Chromosome Position
GRCz10 2 16957281
GRCz11 2 16625871
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
GCAGTTTGCCAAGCAGGTCCTGCCCTTTCCATATCAGACCATTGTGAAGG[T/G]AAATATTCGCACCAAAACAAAATATTCATGAATAAACGTCAGCATTAAAA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa6008
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2018.
Mutation:
A > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000121772   None 504 None 18
ENSDART00000125413 Nonsense 1043 1697 27 42
Genomic Location (Zv9):
Chromosome 2 (position 16451964)
Other Location(s):
Assembly Chromosome Position
GRCz10 2 16962791
GRCz11 2 16631381
KASP Assay ID:
554-3881.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
TCCAAGAGATCCAGGGCTGGWTGAAAACGCATCCAGTGAGCTCCATCTCC[A/T]GAGCATCATGTGATCTGCAGATCCTGGATGCTGGTATTGTGGAGAAGATT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa32874
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
T > G
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000121772   None 504 None 18
ENSDART00000125413 Essential Splice Site 1067 1697 27 42
Genomic Location (Zv9):
Chromosome 2 (position 16452040)
Other Location(s):
Assembly Chromosome Position
GRCz10 2 16962867
GRCz11 2 16631457
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
GGATGCTGGTATTGTGGAGAAGATTGAGGAGGAGCTGGAGAAAACGAAGG[T/G]GAGGATCACATACAAAAATTGACAATCACAGTTACTGTTGCTGGCATTAC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa45094
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2018.
Mutation:
T > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000121772   None 504 None 18
ENSDART00000125413 Nonsense 1139 1697 30 42
Genomic Location (Zv9):
Chromosome 2 (position 16453157)
Other Location(s):
Assembly Chromosome Position
GRCz10 2 16963984
GRCz11 2 16632574
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
AGCTTCCACTTTTATTGTTCAACAGCTGACCGTGAGGCTGAAATTCTATA[T/A]GAGGTGATATTTGATGAGGAGTTTGCTGGAGGACTCACTATCAGGTACAG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa39802
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2018.
Mutation:
C > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000121772   None 504 None 18
ENSDART00000125413 Nonsense 1249 1697 32 42
Genomic Location (Zv9):
Chromosome 2 (position 16456205)
Other Location(s):
Assembly Chromosome Position
GRCz10 2 16967032
GRCz11 2 16635622
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
ACACTCAGGGCAACAGGAACTCGCCACATAAAGCCCTCAACCAGAGAAAC[C/T]AACAAAAGGTATGAAGTGTGAGGTTAATAGGCCTTTTCTGCTGTGGGGGT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa19715
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
T > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000121772   None 504 None 18
ENSDART00000125413 Nonsense 1488 1697 39 42
Genomic Location (Zv9):
Chromosome 2 (position 16463553)
Other Location(s):
Assembly Chromosome Position
GRCz10 2 16974380
GRCz11 2 16642970
KASP Assay ID:
2259-1800.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
TTTCATATCATTTGCTCTTTTCTCTATGTTCTGCAGAGTCTGATCTTGTG[T/A]CAGGTGAAGTTGTCGAATGGTCTGATGGTTCACGGCCCTCAGTGTCAGTC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa19716
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
G > A
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000121772   None 504 None 18
ENSDART00000125413 Essential Splice Site 1607 1697 41 42
Genomic Location (Zv9):
Chromosome 2 (position 16464644)
Other Location(s):
Assembly Chromosome Position
GRCz10 2 16975471
GRCz11 2 16644061
KASP Assay ID:
2259-1801.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
CTGTGCCATCAGCAGCCGGCGGATCCCATAACCAGTTTGTTCCCCTTCAG[G/A]TAATGATTTGCGTCTAGACATGCACACGGAAATCAGTGGCTGTGTTTACA
Associated Phenotype:
Not determined

OMIM

OMIM information for XRN1

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