Ensembl ID:
Human Orthologues:
PRSS1, PRSS3, PRSS37, U66059.56
Human Descriptions:
protease, serine, 1 (trypsin 1) [Source:HGNC Symbol;Acc:9475]
protease, serine, 3 [Source:HGNC Symbol;Acc:9486]
protease, serine, 37 [Source:HGNC Symbol;Acc:29211]
Trypsin-X3 [Source:UniProtKB/Swiss-Prot;Acc:Q8IYP2]
Mouse Orthologues:
1700074P13Rik, 1810009J06Rik, 2210010C04Rik, AC161768.1, BC048599, Gm10334, Gm4744, Gm5771, Prss1, Prss2, Prss3, Prss37, Try10, Try4, Try5
Mouse Descriptions:
cDNA sequence BC048599 Gene [Source:MGI Symbol;Acc:MGI:3608323]
predicted gene 10334 Gene [Source:MGI Symbol;Acc:MGI:3641889]
predicted gene 4744 Pseudogene [Source:MGI Symbol;Acc:MGI:3643181]
predicted gene 5771 Gene [Source:MGI Symbol;Acc:MGI:3646222]
protease, serine, 1 (trypsin 1) Gene [Source:MGI Symbol;Acc:MGI:98839]
protease, serine, 2 Gene [Source:MGI Symbol;Acc:MGI:102759]
protease, serine, 3 Gene [Source:MGI Symbol;Acc:MGI:102758]
protease, serine, 37 Gene [Source:MGI Symbol;Acc:MGI:1914940]
RIKEN cDNA 1700074P13 gene Gene [Source:MGI Symbol;Acc:MGI:1920731]
RIKEN cDNA 1810009J06 gene Gene [Source:MGI Symbol;Acc:MGI:1920876]
RIKEN cDNA 2210010C04 gene Gene [Source:MGI Symbol;Acc:MGI:1914623]
trypsin 10 Gene [Source:MGI Symbol;Acc:MGI:3687012]
trypsin 4 Gene [Source:MGI Symbol;Acc:MGI:102757]
trypsin 5 Gene [Source:MGI Symbol;Acc:MGI:102756]
trypsinogen 4 [Source:RefSeq peptide;Acc:NP_001096130]


There is 1 allele of this gene:

Allele name Consequence Status Availability Estimate
sa42723 Nonsense Mutation detected in F1 DNA During 2018

Mutation Details

Allele Name:
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
We currently estimate that this allele will be available during 2018.
C > T
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000128910 Nonsense 208 243 5 5
Genomic Location (Zv9):
Chromosome 16 (position 27374087)
Other Location(s):
Assembly Chromosome Position
GRCz10 16 25219774
GRCz11 16 25134806
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
Flanking Sequence:
Associated Phenotype:
Not determined


This gene's human homologue has been identified in the following GWAS studies:

  • Pancreatitis: Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. (View Study)

(GWAS data comes from http://www.genome.gov/gwastudies/.)


If you would like to be informed when the status of this gene changes (for example, a new allele is generated or an allele is made available for distribution) then please enter your details below: