si:dkey-46g23.1

Ensembl ID:
ENSDARG00000079723
ZFIN ID:
ZDB-GENE-070705-475
Human Orthologue:
TNRC6B
Human Description:
trinucleotide repeat containing 6B [Source:HGNC Symbol;Acc:29190]
Mouse Orthologue:
Tnrc6b
Mouse Description:
trinucleotide repeat containing 6b Gene [Source:MGI Symbol;Acc:MGI:2443730]

Alleles

There is 1 allele of this gene:

Allele name Consequence Status Availability Estimate
sa8537 Nonsense Mutation detected in F1 DNA During 2018

Mutation Details

Allele Name:
sa8537
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2018.
Mutation:
C > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000108589   None 776 None 17
ENSDART00000109428 Nonsense 15 808 1 17
ENSDART00000132746   None 118 None 3
ENSDART00000133089   None 153 None 4
ENSDART00000140482   None 315 None 5
ENSDART00000145824   None 251 None 5
Genomic Location (Zv9):
Chromosome 3 (position 3894323)
Other Location(s):
Assembly Chromosome Position
GRCz10 3 3578873
GRCz11 3 3361126
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
GYCGGAAGATGGACATTGAYGACGGCACCTCTGCATGGGGGGATCCGTCM[C/T]GATACAGCAGCAAGAAYGTCAATCTGTGGGATAAGAACAGCTCGCAKCCC
Associated Phenotype:
Not determined

GWAS

This gene's human homologue has been identified in the following GWAS studies:

  • Height: A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation. (View Study)
  • Prostate cancer: A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease. (View Study)
  • Prostate cancer: Sequence variants at 22q13 are associated with prostate cancer risk. (View Study)
  • Prostate cancer (gene x gene interaction): A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (View Study)
  • Uterine fibroids: A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids. (View Study)

(GWAS data comes from http://www.genome.gov/gwastudies/.)

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