Ensembl ID:
chromobox 6 [Source:RefSeq peptide;Acc:NP_001003768]
Human Orthologues:
Human Descriptions:
amyloid P component, serum [Source:HGNC Symbol;Acc:584]
C-reactive protein, pentraxin-related [Source:HGNC Symbol;Acc:2367]
Mouse Orthologues:
1810030J14Rik, Apcs, Crp, Gm11062
Mouse Descriptions:
C-reactive protein, pentraxin-related Gene [Source:MGI Symbol;Acc:MGI:88512]
predicted gene 11062 Gene [Source:MGI Symbol;Acc:MGI:3779286]
RIKEN cDNA 1810030J14 gene Gene [Source:MGI Symbol;Acc:MGI:1913539]
serum amyloid P-component Gene [Source:MGI Symbol;Acc:MGI:98229]


There is 1 allele of this gene:

Allele name Consequence Status Availability Estimate
sa45775 Nonsense Mutation detected in F1 DNA During 2018

Mutation Details

Allele Name:
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
We currently estimate that this allele will be available during 2018.
C > T
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000104812 Nonsense 156 411 5 6
ENSDART00000147480 Nonsense 156 462 5 5
Genomic Location (Zv9):
Chromosome 22 (position 31651793)
Other Location(s):
Assembly Chromosome Position
GRCz10 22 29130871
GRCz11 22 29080066
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
Flanking Sequence:
Associated Phenotype:
Not determined


This gene's human homologue has been identified in the following GWAS studies:

  • C-reactive protein: C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans. (View Study)
  • C-reactive protein: Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. (View Study)
  • C-reactive protein: Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. (View Study)
  • C-reactive protein: Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus. (View Study)
  • C-reactive protein: Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment. (View Study)
  • C-reactive protein: Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study. (View Study)
  • C-reactive protein: Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. (View Study)
  • C-reactive protein: Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein. (View Study)
  • Inflammatory biomarkers: A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation. (View Study)
  • Lung cancer: Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. (View Study)
  • Metabolic traits: Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. (View Study)
  • Protein quantitative trait loci: A genome-wide association study identifies protein quantitative trait loci (pQTLs). (View Study)
  • Select biomarker traits: Genome-wide association with select biomarker traits in the Framingham Heart Study. (View Study)

(GWAS data comes from http://www.genome.gov/gwastudies/.)


If you would like to be informed when the status of this gene changes (for example, a new allele is generated or an allele is made available for distribution) then please enter your details below: