sulf1

Ensembl ID:
ENSDARG00000038428
ZFIN ID:
ZDB-GENE-030131-9242
Description:
extracellular sulfatase Sulf-1 [Source:RefSeq peptide;Acc:NP_001003846]
Human Orthologue:
SULF1
Human Description:
sulfatase 1 [Source:HGNC Symbol;Acc:20391]
Mouse Orthologue:
Sulf1
Mouse Description:
sulfatase 1 Gene [Source:MGI Symbol;Acc:MGI:2138563]

Alleles

There are 5 alleles of this gene:

Allele name Consequence Status Availability Estimate
sa37866 Nonsense Mutation detected in F1 DNA During 2018
sa9192 Nonsense Mutation detected in F1 DNA During 2018
sa199 Nonsense Available for shipment Available now
sa37867 Essential Splice Site Mutation detected in F1 DNA During 2018
sa11702 Nonsense Available for shipment Available now

Mutation Details

Allele Name:
sa37866
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2018.
Mutation:
G > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000027022 Nonsense 116 874 3 20
ENSDART00000056080 Nonsense 116 892 3 21
ENSDART00000056081 Nonsense 116 1099 3 19
ENSDART00000137175   None 118 None 4
ENSDART00000140379 Nonsense 116 874 2 19
ENSDART00000142830 Nonsense 116 892 2 20

The following transcripts of ENSDARG00000038428 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 24 (position 20093964)
Other Location(s):
Assembly Chromosome Position
GRCz10 24 19400118
GRCz11 24 19544537
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
CCACAATCACAACACCTACACCAACAATGAGAACTGCTCGTCACCTTCAT[G/A]GCAAGCTCAGCATGAGCCACGATCTTTTGCAGTTTATCTTAACAACACTG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa9192
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2018.
Mutation:
C > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000027022 Nonsense 518 874 11 20
ENSDART00000056080 Nonsense 518 892 11 21
ENSDART00000056081 Nonsense 518 1099 11 19
ENSDART00000137175   None 118 None 4
ENSDART00000140379 Nonsense 518 874 10 19
ENSDART00000142830 Nonsense 518 892 10 20

The following transcripts of ENSDARG00000038428 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 24 (position 20120670)
Other Location(s):
Assembly Chromosome Position
GRCz10 24 19426824
GRCz11 24 19571243
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
AGAAAGACTGCCATTGTGGTGAACGGCCTTACAAAGCAGCCAAAGCAGCA[C/T]RACGGGCACACAGAMAATTCGGACAGAGCAGTAACCCACGTAAGTATGGT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa199
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
C > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000027022 Nonsense 569 874 12 20
ENSDART00000056080 Nonsense 569 892 12 21
ENSDART00000056081 Nonsense 569 1099 12 19
ENSDART00000137175   None 118 None 4
ENSDART00000140379 Nonsense 569 874 11 19
ENSDART00000142830 Nonsense 569 892 11 20

The following transcripts of ENSDARG00000038428 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 24 (position 20123653)
Other Location(s):
Assembly Chromosome Position
GRCz10 24 19429807
GRCz11 24 19574226
KASP Assay ID:
554-0110.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
AAATCTATGACGTTGATCTGCAGGCTGATGATAAAACGCCACTCGAGCCT[C/T]GACCAATCAGCAAGCGCCACTATGAGCCAGAGCCAGGTTTTGATTCGGAC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa37867
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2018.
Mutation:
A > G
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000027022 Essential Splice Site 853 874 19 20
ENSDART00000056080 Essential Splice Site 853 892 19 21
ENSDART00000056081   None 1099 None 19
ENSDART00000137175 Essential Splice Site 89 118 3 4
ENSDART00000140379 Essential Splice Site 853 874 18 19
ENSDART00000142830 Essential Splice Site 853 892 18 20

The following transcripts of ENSDARG00000038428 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 24 (position 20132577)
Other Location(s):
Assembly Chromosome Position
GRCz10 24 19438731
GRCz11 24 19583150
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
TTAAATCGCAAAAGACATTAAACATTTGAATTGCTCTTATTTTCCTGATC[A/G]GGAAGTAAAGATGGAGGAAGCTATGATCAACACAGGTATCCATACTTTTT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa11702
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000027022   None 874 20 20
ENSDART00000056080   None 892 21 21
ENSDART00000056081 Nonsense 1002 1099 19 19
ENSDART00000137175   None 118 None 4
ENSDART00000140379   None 874 None 19
ENSDART00000142830   None 892 None 20

The following transcripts of ENSDARG00000038428 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 24 (position 20135720)
Other Location(s):
Assembly Chromosome Position
GRCz10 24 19441874
GRCz11 24 19586293
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
GAGCCCCCTTCCACGCGGAGACACCTGGKTTCATCAGCTGGAAAATGAGT[T/A]GGGCGATGATGGATTGACGTTTAGTGGCAATGGCGTCACTGAACTAGAGA
Associated Phenotype:
Not determined

GWAS

This gene's human homologue has been identified in the following GWAS studies:

(GWAS data comes from http://www.genome.gov/gwastudies/.)

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