Ensembl ID:
prostaglandin E2 receptor EP4 subtype [Source:RefSeq peptide;Acc:NP_001121839]
Human Orthologue:
Human Description:
prostaglandin E receptor 4 (subtype EP4) [Source:HGNC Symbol;Acc:9596]
Mouse Orthologue:
Mouse Description:
prostaglandin E receptor 4 (subtype EP4) Gene [Source:MGI Symbol;Acc:MGI:104311]


There is 1 allele of this gene:

Allele name Consequence Status Availability Estimate
sa2190 Nonsense F2 line generated During 2018

Mutation Details

Allele Name:
Current Status:
F2 line generated
For more information about the meaning of this status and other statuses, please see our FAQs.
We currently estimate that this allele will be available during 2018.
T > A
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000098010 Nonsense 108 497 1 2
Genomic Location (Zv9):
Chromosome 5 (position 37016966)
Other Location(s):
Assembly Chromosome Position
GRCz10 5 34798915
GRCz11 5 35399068
KASP Assay ID:
554-2434.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
Associated Phenotype:
Not determined


This gene's human homologue has been identified in the following GWAS studies:

  • Ankylosing spondylitis: Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. (View Study)
  • Crohn's disease: A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300. (View Study)
  • Crohn's disease: A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (View Study)
  • Crohn's disease: Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. (View Study)
  • Crohn's disease: Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (View Study)
  • Crohn's disease: Systematic association mapping identifies NELL1 as a novel IBD disease gene. (View Study)
  • Gastric cancer: A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1. (View Study)
  • Multiple sclerosis: Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (View Study)
  • Multiple sclerosis: Genome-wide association study of multiple sclerosis confirms a novel locus at 5p13.1. (View Study)
  • Multiple sclerosis: Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. (View Study)
  • Ulcerative colitis: Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (View Study)
  • Ulcerative colitis: Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (View Study)

(GWAS data comes from


If you would like to be informed when the status of this gene changes (for example, a new allele is generated or an allele is made available for distribution) then please enter your details below: