ctnna2

Ensembl ID:
ENSDARG00000024785
ZFIN ID:
ZDB-GENE-060815-3
Description:
Catenin alpha-2 [Source:UniProtKB/Swiss-Prot;Acc:B7ZC77]
Human Orthologue:
CTNNA2
Human Description:
catenin (cadherin-associated protein), alpha 2 [Source:HGNC Symbol;Acc:2510]
Mouse Orthologue:
Ctnna2
Mouse Description:
catenin (cadherin associated protein), alpha 2 Gene [Source:MGI Symbol;Acc:MGI:88275]

Alleles

There are 4 alleles of this gene:

Allele name Consequence Status Availability Estimate
sa16103 Nonsense Available for shipment Available now
sa32731 Nonsense Mutation detected in F1 DNA During 2018
sa2006 Nonsense F2 line generated During 2018
sa32732 Nonsense Mutation detected in F1 DNA During 2018

Mutation Details

Allele Name:
sa16103
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000017139   None 352 None 7
ENSDART00000101306 Nonsense 396 865 9 17
ENSDART00000101311   None 293 None 7
ENSDART00000110860   None 373 None 7
ENSDART00000138740   None 430 None 9
ENSDART00000143871   None 271 None 5

The following transcripts of ENSDARG00000024785 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 1 (position 43362451)
Other Location(s):
Assembly Chromosome Position
GRCz10 1 42278767
GRCz11 1 42979931
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
GCTCACCAACATCATWCTTTCTGTGTTTTTCAGGTGGCCAACCTCGCCTG[T/A]TCCATCTCCAACAATGAGGAGGGGGTGAAGYTAGTGCGCATGGCTGCTAC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa32731
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2018.
Mutation:
C > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000017139   None 352 None 7
ENSDART00000101306 Nonsense 414 865 9 17
ENSDART00000101311   None 293 None 7
ENSDART00000110860   None 373 None 7
ENSDART00000138740   None 430 None 9
ENSDART00000143871   None 271 None 5

The following transcripts of ENSDARG00000024785 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 1 (position 43362503)
Other Location(s):
Assembly Chromosome Position
GRCz10 1 42278819
GRCz11 1 42979983
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
CCATCTCCAACAATGAGGAGGGGGTGAAGTTAGTGCGCATGGCTGCTACA[C/T]AGATCGATAGCCTGTGTCCTCAGGTAAAAAGGCCAGAACCTTCTGCTATC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa2006
Current Status:
F2 line generated
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2018.
Mutation:
C > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000017139   None 352 None 7
ENSDART00000101306 Nonsense 646 865 14 17
ENSDART00000101311   None 293 None 7
ENSDART00000110860   None 373 None 7
ENSDART00000138740   None 430 None 9
ENSDART00000143871   None 271 None 5
ENSDART00000017139   None 352 None 7
ENSDART00000101306 Nonsense 646 865 14 17
ENSDART00000101311   None 293 None 7
ENSDART00000110860   None 373 None 7
ENSDART00000138740   None 430 None 9
ENSDART00000143871   None 271 None 5

The following transcripts of ENSDARG00000024785 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 1 (position 43405283)
Other Location(s):
Assembly Chromosome Position
GRCz10 1 42321599
GRCz11 1 43022763
KASP Assay ID:
554-3244.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
AGGCCATCATGGCTCAGCTGCCTCAGGAAGAAAAGGCCAAGATTGCTGAA[C/T]AGGTCGAGAGCTTCAGGCAGGAAAAGAGCAAGCTGGACGCTGAAGTCGCT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa32732
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2018.
Mutation:
C > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000017139   None 352 None 7
ENSDART00000101306 Nonsense 677 865 14 17
ENSDART00000101311   None 293 None 7
ENSDART00000110860   None 373 None 7
ENSDART00000138740   None 430 None 9
ENSDART00000143871   None 271 None 5

The following transcripts of ENSDARG00000024785 do not overlap with this mutation:

Genomic Location (Zv9):
Chromosome 1 (position 43405376)
Other Location(s):
Assembly Chromosome Position
GRCz10 1 42321692
GRCz11 1 43022856
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
AAGTCGCTAAGTGGGATGACAATGGAAATGACATCATCGTGTTGGCTAAG[C/T]AGATGTGTATGATCATGATGGAGATGACTGACTTCACCAGGTACATCCGC
Associated Phenotype:
Not determined

GWAS

This gene's human homologue has been identified in the following GWAS studies:

(GWAS data comes from http://www.genome.gov/gwastudies/.)

OMIM

OMIM information for CTNNA2

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