arhgef18

Ensembl ID:
ENSDARG00000011157
ZFIN ID:
ZDB-GENE-040516-14
Description:
rho/rac guanine nucleotide exchange factor (GEF) 18 [Source:RefSeq peptide;Acc:NP_999983]
Human Orthologue:
ARHGEF18
Human Description:
Rho/Rac guanine nucleotide exchange factor (GEF) 18 [Source:HGNC Symbol;Acc:17090]
Mouse Orthologue:
Arhgef18
Mouse Description:
rho/rac guanine nucleotide exchange factor (GEF) 18 Gene [Source:MGI Symbol;Acc:MGI:2142567]

Alleles

There are 6 alleles of this gene:

Allele name Consequence Status Availability Estimate
sa1637 Nonsense F2 line generated During 2018
sa25861 Essential Splice Site Mutation detected in F1 DNA During 2018
sa16319 Essential Splice Site Available for shipment Available now
sa19819 Nonsense Available for shipment Available now
sa38343 Essential Splice Site Mutation detected in F1 DNA During 2018
sa39886 Nonsense Mutation detected in F1 DNA During 2018

Mutation Details

Allele Name:
sa1637
Current Status:
F2 line generated
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2018.
Mutation:
G > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000025841 Nonsense 41 940 5 21
ENSDART00000133951 Nonsense 41 68 4 4
ENSDART00000143496 Nonsense 41 73 6 6
Genomic Location (Zv9):
Chromosome 2 (position 37247605)
Other Location(s):
Assembly Chromosome Position
GRCz10 2 37544315
GRCz11 2 37526772
KASP Assay ID:
554-1577.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
ATCTCGTCATCTACACAGAATGCCATTATAATGTGCTGCGTGACGATCTG[G/T]AGTCCGATGCTCGGGACTTTGAGGCTCCSACCWGGAGTTTAGCTGTTGAC
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa25861
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2018.
Mutation:
T > A
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000025841 Essential Splice Site 77 940 5 21
ENSDART00000133951   None 68 None 4
ENSDART00000143496   None 73 None 6
ENSDART00000025841 Essential Splice Site 77 940 5 21
ENSDART00000133951   None 68 None 4
ENSDART00000143496   None 73 None 6
Genomic Location (Zv9):
Chromosome 2 (position 37247495)
Other Location(s):
Assembly Chromosome Position
GRCz10 2 37544205
GRCz11 2 37526662
KASP Assay ID:
554-6245.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
TTGAAAAACTTTTCCAAAGATGCCGTCAAAAGACAGGATGTAATACACGG[T/A]AAGGGACTGTGGTCTATTTTTGTTGTTTATTTGTTTATTTGTTTTTCATG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa16319
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > G
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000025841 Essential Splice Site 77 940 5 21
ENSDART00000133951   None 68 None 4
ENSDART00000143496   None 73 None 6
ENSDART00000025841 Essential Splice Site 77 940 5 21
ENSDART00000133951   None 68 None 4
ENSDART00000143496   None 73 None 6
Genomic Location (Zv9):
Chromosome 2 (position 37247495)
Other Location(s):
Assembly Chromosome Position
GRCz10 2 37544205
GRCz11 2 37526662
KASP Assay ID:
554-6245.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
TTGAAAAACTTTTCCAAAGATGCCGWCAAAAGACAGGATGTAATACACGG[T/G]AAGGGACTGTGGTCTWTTTTTKTTNGTTTATTTGTTTATTTGTTTTWCATG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa19819
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
C > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000025841 Nonsense 110 940 6 21
ENSDART00000133951   None 68 None 4
ENSDART00000143496   None 73 None 6
Genomic Location (Zv9):
Chromosome 2 (position 37247294)
Other Location(s):
Assembly Chromosome Position
GRCz10 2 37544004
GRCz11 2 37526461
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
TGAATGTGTACATTCGGGAGTTGCGTAACACCCTACAAATGGATGAGACA[C/T]GACTGGAAAGGCTGTTTCCACAGGTGGAAAACCTGCTGGAGGTGCACCAG
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa38343
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2018.
Mutation:
G > A
Consequence:
Essential Splice Site
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000025841 Essential Splice Site 331 940 9 21
ENSDART00000133951   None 68 None 4
ENSDART00000143496   None 73 None 6
Genomic Location (Zv9):
Chromosome 2 (position 37242456)
Other Location(s):
Assembly Chromosome Position
GRCz10 2 37539166
GRCz11 2 37521623
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
GCTCAACTGGAGGGTCACGAACAACAAAGGCAAAGGTGATAAGCATACAG[G/A]TGAGATAAAAATTACAGCTGGATTATCTAGTAGTTGTTTACCAATCTTGA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa39886
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2018.
Mutation:
C > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000025841 Nonsense 491 940 13 21
ENSDART00000133951   None 68 None 4
ENSDART00000143496   None 73 None 6
Genomic Location (Zv9):
Chromosome 2 (position 37235649)
Other Location(s):
Assembly Chromosome Position
GRCz10 2 37532359
GRCz11 2 37514816
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
GTGAGCGCCATCCGCTACGTGGGAATGCAGCAGAGCCCCTGCAGGGAGAA[C/T]GACTACTCACCGGAGCCCTGAAAGATGGTGAGATTTACACTGCACAGTAC
Associated Phenotype:
Not determined

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