slit2

Ensembl ID:
ENSDARG00000004246
ZFIN ID:
ZDB-GENE-010306-3
Description:
slit homolog 2 protein [Source:RefSeq peptide;Acc:NP_571810]
Human Orthologue:
SLIT2
Human Description:
slit homolog 2 (Drosophila) [Source:HGNC Symbol;Acc:11086]
Mouse Orthologue:
Slit2
Mouse Description:
slit homolog 2 (Drosophila) Gene [Source:MGI Symbol;Acc:MGI:1315205]

Alleles

There are 5 alleles of this gene:

Allele name Consequence Status Availability Estimate
sa231 Nonsense Confirmed mutation in F2 line During 2018
sa15818 Nonsense Available for shipment Available now
sa1772 Nonsense Available for shipment Available now
sa39610 Nonsense Mutation detected in F1 DNA During 2018
sa12974 Nonsense Available for shipment Available now

Mutation Details

Allele Name:
sa231
Current Status:
Confirmed mutation in F2 line
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2018.
Mutation:
T > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000007531 Nonsense 378 1512 13 36
Genomic Location (Zv9):
Chromosome 1 (position 22636966)
Other Location(s):
Assembly Chromosome Position
GRCz10 1 23172133
GRCz11 1 23862872
KASP Assay ID:
554-0161.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
TGCGAATGTTTATCCCAACAGATTGCTGAATGCGAACAAGATCAATTGTT[T/A]GCGTGTAGATTCTTTCCAAGACCTGCAGAATCTGAATCTTCTGTCGCTTT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa15818
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000007531 Nonsense 603 1512 18 36
Genomic Location (Zv9):
Chromosome 1 (position 22644693)
Other Location(s):
Assembly Chromosome Position
GRCz10 1 23179860
GRCz11 1 23870599
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
GGGTCTCTGTTTGTCACATGTAGGATGTTGAGGAGTAACAGGATAAGCTG[T/A]GTCAATAACGGCAGTTTTACCGGTCTGAGCTCTGTGAGGTTGCTTTCCCT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa1772
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Mutation:
T > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000007531 Nonsense 716 1512 20 36
Genomic Location (Zv9):
Chromosome 1 (position 22648095)
Other Location(s):
Assembly Chromosome Position
GRCz10 1 23183262
GRCz11 1 23874001
KASP Assay ID:
554-1765.1 (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
GATGAGAATAGCTGTTCACCACTGGCTCGCTGTCCTGCCGAGTGTTCGTG[T/A]TTGGATACAGTGGTTCGTTGCAGTAATAAAGGACTCAAGGTTYTGCCTAA
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa39610
Current Status:
Mutation detected in F1 DNA
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
We currently estimate that this allele will be available during 2018.
Mutation:
C > T
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000007531 Nonsense 1320 1512 34 36
Genomic Location (Zv9):
Chromosome 1 (position 22677101)
Other Location(s):
Assembly Chromosome Position
GRCz10 1 23212268
GRCz11 1 23903007
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
None
Flanking Sequence:
TCACCCAGTTTTTGCTGCAGGAGGGTGTTGTGCCCGGATGCCAGCCATGC[C/T]AGCGGAGCATGTGTGCTCATGGCCAGTGCCATGCCACTGGACAGTCCTCT
Associated Phenotype:
Not determined

Mutation Details

Allele Name:
sa12974
Current Status:
Available for shipment
For more information about the meaning of this status and other statuses, please see our FAQs.
Availability:
Order Allele From ZIRC
Order Allele From EZRC
Mutation:
T > A
Consequence:
Nonsense
Transcript ID Consequence Amino Acid Affected Amino Acid Total Exon Affected Exon Total
ENSDART00000007531 Nonsense 1462 1512 36 36
Genomic Location (Zv9):
Chromosome 1 (position 22682645)
Other Location(s):
Assembly Chromosome Position
GRCz10 1 23217812
GRCz11 1 23908551
KASP Assay ID:
None (used for ordering genotyping assays from LGC Genomics)
KASP Sequence:
GACGCAGCAGGGCTACGCCGCGTGCCAGAGCACAGAGAAGGTCTCGCGTT[T/A]AGAGTGTCGGGGCAGCTGTGGGGRYGGGACCTCCTGCTGCGCCCCGCTCC
Associated Phenotype:
Not determined

GWAS

This gene's human homologue has been identified in the following GWAS studies:

  • Exercise treadmill test traits: Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (View Study)

(GWAS data comes from http://www.genome.gov/gwastudies/.)

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