The Genome informatics group, under Dr Richard Durbin, works on various types of sequence and variation informatics, mostly in one way or another involving evolutionary analysis.
[Kate Whitley, Wellcome Images]
Apart from human genome resequencing, projects that Richard is connected to include:
- the SGRP yeast sequence variation and population genomics project;
- the TreeFam database of animal gene families;
- the Ensembl resource for vertebrate genome annotation;
- the WormBase model organism database for C. elegans;
- the MitoCheck study of mitosis regulation in human cells;
- the Pfam database of protein domain families; and
- the ACEDB genome database.
- 1000 Genomes Project, a deep catalogue of human genetic variation.
- SGRP, Saccharomyces Genome Resequencing Project.
- WormBase is the repository of mapping, sequencing and phenotypic information for C. elegans and several related nematodes. It also contains large amounts of data from manually curated papers and genome wide studies.
- TreeFam, tree families database.
- Margarita, inferring genealogies from population genotype data and using these to map disease loci.
- MAQ, software for mapping short sequencing reads
The Sequence Alignment/Map format and SAMtools.
Bioinformatics (Oxford, England) 2009;25;16;2078-9
The consensus coding sequence (CCDS) project: Identifying a common protein-coding gene set for the human and mouse genomes.
Genome research 2009;19;7;1316-23
Population genomics of domestic and wild yeasts.
Inferring selection on amino acid preference in protein domains.
Molecular biology and evolution 2008;26;3;527-36
Accurate whole human genome sequencing using reversible terminator chemistry.
Mapping short DNA sequencing reads and calling variants using mapping quality scores.
Genome research 2008;18;11;1851-8
Mapping trait loci by use of inferred ancestral recombination graphs.
American journal of human genetics 2006;79;5;910-22
TreeFam: a curated database of phylogenetic trees of animal gene families.
Nucleic acids research 2006;34;Database issue;D572-80
No team members listed