Dr Vijay Yadav

Vijay's laboratory uses mouse genetic, genomic, and proteomic approaches to investigate how molecules originating from within, and outside the bone regulate bone remodelling.

Vijay graduated from University of Lucknow with a BSc in Biology in 1997 and went on to complete his MSc in Biochemistry in 1999. He earned his PhD in Molecular Reproductive Physiology from the Indian Institute of Science, Bangalore in 2005.

During his doctoral work, Vijay used rodent, bovine and primate model organisms to explore how pituitary hormones regulate ovarian function during female reproductive cycles. During the course of these studies, he became interested in osteoporosis, a disease that predominantly affects females after ovarian failure. This research led him to his postdoctoral work, trying to identify novel endocrine interactions that regulate bone cell functions, with Gerard Karsenty at Columbia University. During the last few years, Vijay's work has illustrated novel endocrine interactions in the brain and gut that regulate bone mass.

In 2010, Vijay joined the Wellcome Trust Sanger Institute as a Faculty member in the Mouse and Zebrafish Genetics programme.

Selected Publications

  • Vitamin B₁₂-dependent taurine synthesis regulates growth and bone mass.

    Roman-Garcia P, Quiros-Gonzalez I, Mottram L, Lieben L, Sharan K, Wangwiwatsin A, Tubio J, Lewis K, Wilkinson D, Santhanam B, Sarper N, Clare S, Vassiliou GS, Velagapudi VR, Dougan G and Yadav VK

    The Journal of clinical investigation 2014;124;7;2988-3002

  • Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.

    arcOGEN Consortium, arcOGEN Collaborators, Zeggini E, Panoutsopoulou K, Southam L, Rayner NW, Day-Williams AG, Lopes MC, Boraska V, Esko T, Evangelou E, Hoffman A, Houwing-Duistermaat JJ, Ingvarsson T, Jonsdottir I, Jonnson H, Kerkhof HJ, Kloppenburg M, Bos SD, Mangino M, Metrustry S, Slagboom PE, Thorleifsson G, Raine EV, Ratnayake M, Ricketts M, Beazley C, Blackburn H, Bumpstead S, Elliott KS, Hunt SE, Potter SC, Shin SY, Yadav VK, Zhai G, Sherburn K, Dixon K, Arden E, Aslam N, Battley PK, Carluke I, Doherty S, Gordon A, Joseph J, Keen R, Koller NC, Mitchell S, O'Neill F, Paling E, Reed MR, Rivadeneira F, Swift D, Walker K, Watkins B, Wheeler M, Birrell F, Ioannidis JP, Meulenbelt I, Metspalu A, Rai A, Salter D, Stefansson K, Stykarsdottir U, Uitterlinden AG, van Meurs JB, Chapman K, Deloukas P, Ollier WE, Wallis GA, Arden N, Carr A, Doherty M, McCaskie A, Willkinson JM, Ralston SH, Valdes AM, Spector TD and Loughlin J

    Lancet 2012;380;9844;815-23

  • Efficacy of serotonin inhibition in mouse models of bone loss.

    Inose H, Zhou B, Yadav VK, Guo XE, Karsenty G and Ducy P

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011;26;9;2002-11

  • Leptin-dependent serotonin control of appetite: temporal specificity, transcriptional regulation, and therapeutic implications.

    Yadav VK, Oury F, Tanaka KF, Tanaka K, Thomas T, Wang Y, Cremers S, Hen R, Krust A, Chambon P and Karsenty G

    The Journal of experimental medicine 2011;208;1;41-52

  • CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neurons.

    Oury F, Yadav VK, Wang Y, Zhou B, Liu XS, Guo XE, Tecott LH, Schutz G, Means AR and Karsenty G

    Genes & development 2010;24;20;2330-42

  • Genetic analysis of Lrp5 function in osteoblast progenitors.

    Yadav VK, Arantes HP, Barros ER, Lazaretti-Castro M and Ducy P

    Calcified tissue international 2010;86;5;382-8

  • Signaling through the M(3) muscarinic receptor favors bone mass accrual by decreasing sympathetic activity.

    Shi Y, Oury F, Yadav VK, Wess J, Liu XS, Guo XE, Murshed M and Karsenty G

    Cell metabolism 2010;11;3;231-8

  • Patients with high-bone-mass phenotype owing to Lrp5-T253I mutation have low plasma levels of serotonin.

    Frost M, Andersen TE, Yadav V, Brixen K, Karsenty G and Kassem M

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2010;25;3;673-5

  • Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis.

    Yadav VK, Balaji S, Suresh PS, Liu XS, Lu X, Li Z, Guo XE, Mann JJ, Balapure AK, Gershon MD, Medhamurthy R, Vidal M, Karsenty G and Ducy P

    Nature medicine 2010;16;3;308-12

  • A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure.

    Yadav VK, Oury F, Suda N, Liu ZW, Gao XB, Confavreux C, Klemenhagen KC, Tanaka KF, Gingrich JA, Guo XE, Tecott LH, Mann JJ, Hen R, Horvath TL and Karsenty G

    Cell 2009;138;5;976-89

  • The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity.

    Hinoi E, Gao N, Jung DY, Yadav V, Yoshizawa T, Myers MG, Chua SC, Kim JK, Kaestner KH and Karsenty G

    The Journal of cell biology 2008;183;7;1235-42

  • Dissociation of the neuronal regulation of bone mass and energy metabolism by leptin in vivo.

    Shi Y, Yadav VK, Suda N, Liu XS, Guo XE, Myers MG and Karsenty G

    Proceedings of the National Academy of Sciences of the United States of America 2008;105;51;20529-33

  • Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum.

    Yadav VK, Ryu JH, Suda N, Tanaka KF, Gingrich JA, Schütz G, Glorieux FH, Chiang CY, Zajac JD, Insogna KL, Mann JJ, Hen R, Ducy P and Karsenty G

    Cell 2008;135;5;825-37

  • Dynamic changes in mitogen-activated protein kinase (MAPK) activities in the corpus luteum of the bonnet monkey (Macaca radiata) during development, induced luteolysis, and simulated early pregnancy: a role for p38 MAPK in the regulation of luteal function.

    Yadav VK and Medhamurthy R

    Endocrinology 2006;147;4;2018-27

  • Prostaglandin F2alpha-mediated activation of apoptotic signaling cascades in the corpus luteum during apoptosis: involvement of caspase-activated DNase.

    Yadav VK, Lakshmi G and Medhamurthy R

    The Journal of biological chemistry 2005;280;11;10357-67

  • Identification of novel genes regulated by LH in the primate corpus luteum: insight into their regulation during the late luteal phase.

    Yadav VK, Muraly P and Medhamurthy R

    Molecular human reproduction 2004;10;9;629-39

  • Cloning of a buffalo (Bubalus bubalis) prostaglandin F(2alpha) receptor: changes in its expression and concentration in the buffalo cow corpus luteum.

    Verma-Kumar S, Srinivas SV, Muraly P, Yadav VK and Medhamurthy R

    Reproduction (Cambridge, England) 2004;127;6;705-15

  • Apoptosis during spontaneous and prostaglandin F(2alpha)-induced luteal regression in the buffalo cow (Bubalus bubalis): involvement of mitogen-activated protein kinases.

    Yadav VK, Sudhagar RR and Medhamurthy R

    Biology of reproduction 2002;67;3;752-9

[Genome Research Limited]

Vijay's Project
Systems biology of bone
Research Area
Mouse and Zebrafish
* quick link - http://q.sanger.ac.uk/rotj7jm5