Dr Matthew Sinnott
Senior Data Scientist
My main focus is in developing the reporting infrastructure with which we can report the findings from the Heron Project to external stakeholders, such as public health agencies.
I completed my undergraduate degree in Biochemistry with a Year in Research at Imperial College London in 2016, completing my undergraduate project with Prof. Jake Baum on purification and binding analyses of the Essential Light Chain in Plasmodium falciparum.
During this time I also had the opportunity to work for a year in the Plant Biology and Crop Sciences division at Rothamstead Research. The goal of this project was to investigate changes in cell wall composition in the starchy endosperm of wheat lines which had suppressed/increased expression of certain glycosyl transferases.
I then went on to a 4 year PhD at the Institute of Structural and Molecular Biology (ISMB), a partnership between Birkbeck College and University College London. My main project was with Prof. Maya Topf and Prof. Konstantinos Thalassinos in the development of computational methods to analyse protein structure using data from a technique called Chemical Crosslinking Mass Spectrometry. In this project we published a paper in the journal Structure where we devised a methodology to use monolinks, a previously unused by-product produced in the cross-linking procedure, to score model protein structures.
My Role at Sanger
I am currently working the Data Analysis team in the Heron Project. My main responsibility is in the development of a reporting infrastructure with which we can communicate the findings of the Heron Project’s genomic surveillance activities.
The main focus of this is to use genomic information to identify where a superspreader event has occured, in doing so we hope to be able to provide an early warning system for local authorities of where we may expect to see further increases in case numbers.
My work centers mainly around analysing the data from the Heron pipeline and producing visulisations. I am also focussed on building architectures to present this data such as a web framework.