Applying histology and spatial genomics to explore the evolutionary basis of clinical cancer development and progression

Gavin’s role, within the High Throughput Spatial Genomics initiative, explores the evolutionary basis of clinical cancer progression by combining cutting-edge single cell and spatial RNA-sequencing, high-throughput microscopy and quantitative image data analysis to enable large-scale spatial genomic studies.

Prior to joining the Wellcome Sanger Institute, Gavin was employed as a Clinical Research Scientist in the Medical Devices Industry. Prior to this he worked as a Clinical Vascular STP in the NHS and completed a postdoc at the Barts Cancer Institute under Pathologist Sir Prof Nicholas Wright and Dr Stuart McDonald, collaborating with Prof Marnix Jansen at University College London, investigating stem cell evolution and its involvement in phenotypic characteristics and progression to cancer in FFPE and Frozen Tissue Samples from patients with Gastric Intestinal Metaplasia (IM) and Barrett’s Oesophagus.

His Joint Doctorate in Clinical Medicine (Molecular Oncology) and Biomedical Engineering completed at Imperial College London under the supervision of Dr Sylvain Ladame, Prof Charlotte Bevan, Prof Robert (Bob) Brown, and Prof Charles Coombes primarily focused upon the design and development of synthetic Peptide Nucleic Acid (PNA)-based fluorogenic biosensors for high-throughput profiling and sensing of cancer-specific circulating nucleic acid chains (incl. miRNA) in clinical samples for early-stage detection and diagnosis of hormonal cancers (Prostate, Breast, and Ovarian Cancer).

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