From @davisjmcc, @YuanhuaHuang, @OliverStegle and Teichmann lab: Cardelino leverages variant information from single-cell RNA-seq data for inferring clonal tree configuration and mapping cells to their clone of origin. https://www.nature.com/articles/s41592-020-0766-3
For the first time, the highly dynamic cellular landscape of the human thymus has been charted across a lifespan, according to a new Science report, which may be useful in developing future T-cell therapeutic strategies. ($) https://fcld.ly/kc9mg52
Our work on T-cell lineage commitment and TCR recombination in the native thymic microenvironment across human lifespan is online! Fantastic team led by @park_jongeun, Sarah Teichmann, @Muzz_Haniffa and @taghon_t
https://science.sciencemag.org/content/367/6480/eaay3224.full