Our work is finally out @NatureBiotech! We functionally scored and interpreted nearly 1000 variants in the NPC1 gene using saturation prime editing and locus haploidization ✂️🧬 https://twitter.com/NatureBiotech/status/1495812638735052800
Prime editing can be used to precisely insert short DNA sequences into the genome. But what determines how efficiently any given sequence can be inserted? Joined forces @JulianeWeller, Elin Madli Peets, Ananth Pallaseni, @FabioLib, @LeopoldParts https://www.biorxiv.org/content/10.1101/2021.11.10.468024v1. A 🧵