Dr Caroline Wright | Senior Scientific Manager

This person is a member of Sanger Institute Alumni.

Wright, Caroline

I am the Programme Manager for the Deciphering Developmental Disorders (DDD) Study, a collaboration between the Wellcome Trust Sanger Institute and the 24 regional genetics services across the UK and Ireland. I oversee all aspects of the study, and am particularly involved with clinical anlaysis and reporting of plausibly diagnostic results to clinical teams. As a result of this work, I am also currently seconded part-time to Genomics England, where I am scientific lead for validation and feedback of clinical results from the 100,000 genome project. 

Prior to joining the WTSI, I was Head of Science at the Foundation for Genomics and Population Health (PHG), a health policy think-tank. Amongst other things, I was responsible for writing a Report detailing how next generation sequencing could be used in the NHS.

My PhD was in protein biophysics at the University of Cambridge and I retain a keen interest in understanding the effect of mutations on protein structure.

Programme Manager, UK Deciphering Delopmental Disorders Study


  • Genetic diagnosis of developmental disorders in the DDD study: a scalable analysis of genome-wide research data.

    Wright CF, Fitzgerald TW, Jones WD, Clayton S, McRae JF et al.

    Lancet (London, England) 2015;385;9975;1305-14

  • Large-scale discovery of novel genetic causes of developmental disorders.

    Deciphering Developmental Disorders Study

    Nature 2015;519;7542;223-8

  • Potential research participants support the return of raw sequence data.

    Middleton A, Wright CF, Morley KI, Bragin E, Firth HV et al.

    Journal of medical genetics 2015;52;8;571-4

  • Attitudes of nearly 7000 health professionals, genomic researchers and publics toward the return of incidental results from sequencing research.

    Middleton A, Morley KI, Bragin E, Firth HV, Hurles ME et al.

    European journal of human genetics : EJHG 2016;24;1;21-9

  • Policy challenges of clinical genome sequencing.

    Wright CF, Middleton A, Burton H, Cunningham F, Humphries SE et al.

    BMJ (Clinical research ed.) 2013;347;f6845

  • No expectation to share incidental findings in genomic research.

    Middleton A, Morley KI, Bragin E, Firth HV, Hurles ME et al.

    Lancet (London, England) 2015;385;9975;1289-90

  • Informatics and clinical genome sequencing: opening the black box.

    Moorthie S, Hall A and Wright CF

    Genetics in medicine : official journal of the American College of Medical Genetics 2013;15;3;165-71

  • Non-invasive prenatal diagnostic test accuracy for fetal sex using cell-free DNA a review and meta-analysis.

    Wright CF, Wei Y, Higgins JP and Sagoo GS

    BMC research notes 2012;5;476

  • Review of massively parallel DNA sequencing technologies.

    Moorthie S, Mattocks CJ and Wright CF

    The HUGO journal 2011;5;1-4;1-12

  • The Deciphering Developmental Disorders (DDD) study.

    Firth HV, Wright CF and DDD Study

    Developmental medicine and child neurology 2011;53;8;702-3

  • Realising the benefits of genetics for health.

    Wright CF, Brice P, Stewart A and Burton H

    Lancet (London, England) 2010;376;9750;1370-1

  • The importance of sequence diversity in the aggregation and evolution of proteins.

    Wright CF, Teichmann SA, Clarke J and Dobson CM

    Nature 2005;438;7069;878-81

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