Spain, Sarah L
Sarah is an Operations Manager for Open Targets, an innovative, public-private partnership that uses human genetics and genomics data for systematic drug target identification and prioritisation. She originally joined the Sanger Institute as a post-doctoral statistical geneticist working on the genetics of complex diseases with a focus on Inflammatory Bowel Disease (IBD). In particular, utilising fine-mappng data to infer genes that are potential drug targets.
I have a molecular biology background and moved from the laboratory bench into statistical genetics during my PhD, which focused on the genetic analysis of the Colorectal Cancer genome-wide association study (GWAS). Since then, I have developed my analytical skills through two post-doctoral positions at King's College London. I have worked with GWAS, Immunochip finemapping and exome chip genotype data for a variety of international collaborative projects in complex diseases such as psoriasis, cognitive ability and Inflammatory Bowel Disease.
My scientific interests are focused on the genetic differences between individuals that confer an increased susceptibility to common diseases. In my research, as part of Open Targets, I utilised publically available and in-house tools to analyse large scale genetic data with the aim to identify target genes that may have therapeutic potential for diseases, such as IBD. More recently, I have moved into a research administrator role to facilitate the smooth running of Open Targets research projects.
Strategies for fine-mapping complex traits.
Human molecular genetics 2015;24;R1;R111-9
A genome-wide analysis of putative functional and exonic variation associated with extremely high intelligence.
Molecular psychiatry 2016;21;8;1145-51
Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci.
Nature communications 2015;6;7001
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
Nature genetics 2012;44;12;1341-8
Refinement of the associations between risk of colorectal cancer and polymorphisms on chromosomes 1q41 and 12q13.13.
Human molecular genetics 2012;21;4;934-46
Colorectal cancer risk is not associated with increased levels of homozygosity in a population from the United Kingdom.
Cancer research 2009;69;18;7422-9