Kirton, Christopher Michael
Chris Kirton has a background in molecular immunology and biopharmaceutical drug development, mainly antibodies and vaccines. Prior to joining the Sanger Institute Chris was a post-doc in the Division of Immunology at Cambridge University where he developed a monoclonal antibody against the inflammatory mediator VAP-1 and later became Head of the Cell Biology and Biopharmaceutical areas at ENVIGO, a global CRO.
Activated platelets adherent to an intact endothelial cell monolayer bind flowing neutrophils and enable them to transfer to the endothelial surface.
The Journal of laboratory and clinical medicine 2000;136;4;303-13
Regulation of parietal cell migration by gastrin in the mouse.
American journal of physiology. Gastrointestinal and liver physiology 2002;283;3;G787-93
Gastrin induces proliferation in Barrett's metaplasia through activation of the CCK2 receptor.
COOH-terminal 26-amino acid residues of progastrin are sufficient for stimulation of mitosis in murine colonic epithelium in vivo.
American journal of physiology. Gastrointestinal and liver physiology 2005;288;3;G541-9
Function-blocking antibodies to human vascular adhesion protein-1: a potential anti-inflammatory therapy.
European journal of immunology 2005;35;11;3119-30
PECAM-1 polymorphism affects monocyte adhesion to endothelial cells.
In vitro cytokine release assays: reducing the risk of adverse events in man.
Low-affinity FcγR interactions can decide the fate of novel human IgG-sensitised red blood cells and platelets.
European journal of immunology 2014;44;3;905-14
Clearance of human IgG1-sensitised red blood cells in vivo in humans relates to the in vitro properties of antibodies from alternative cell lines.
PloS one 2014;9;10;e109463
Successful Generation of Human Induced Pluripotent Stem Cell Lines from Blood Samples Held at Room Temperature for up to 48 hr.
Stem cell reports 2015;5;4;660-71