Dr Sarah K Buddenborg | Postdoctoral Fellow

Kay Buddenborg, Sarah

I joined the Parasite Genomics group as a Postdoctoral Fellow in 2018 to perform computational and experimental analyses on the blood fluke Schistosoma mansoni. My interests and experience include general parasitology, invertebrate immunology, NTDs, host-parasite interactions, parasite symbionts (hyperparasites), and disease vectors. 

My first role was to finish the assembly and annotation of the Schistosoma mansoni genome. This project involved a fine-scale and specialized look at the sex chromosomes of schistosomes. Schistosomes are unique among platyhelminths (parasitic flatworms) in that they are dioecious (separate males and females) and dimorphic (two distinct forms) with chromosomal sex determination. I am performing functional genomics experiments on the coding and non-coding regions of the schistosome sex chromosomes to determine the mechanism of sex determination and how it can be manipulated to reduce/eliminate disease burden in this genus of trematodes responsible for the neglected tropical disease, schistosomiasis. 

Publications

  • The in vivo transcriptome of Schistosoma mansoni in the prominent vector species Biomphalaria pfeifferi with supporting observations from Biomphalaria glabrata.

    Buddenborg SK, Kamel B, Hanelt B, Bu L, Zhang SM et al.

    PLoS neglected tropical diseases 2019;13;9;e0007013

  • Transcriptomic responses of Biomphalaria pfeifferi to Schistosoma mansoni: Investigation of a neglected African snail that supports more S. mansoni transmission than any other snail species.

    Buddenborg SK, Bu L, Zhang SM, Schilkey FD, Mkoji GM and Loker ES

    PLoS neglected tropical diseases 2017;11;10;e0005984

  • Whole genome analysis of a schistosomiasis-transmitting freshwater snail.

    Adema CM, Hillier LW, Jones CS, Loker ES, Knight M et al.

    Nature communications 2017;8;15451

  • Altered Gene Expression in the Schistosome-Transmitting Snail Biomphalaria glabrata following Exposure to Niclosamide, the Active Ingredient in the Widely Used Molluscicide Bayluscide.

    Zhang SM, Buddenborg SK, Adema CM, Sullivan JT and Loker ES

    PLoS neglected tropical diseases 2015;9;10;e0004131

  • Differential expression of small RNAs from Burkholderia thailandensis in response to varying environmental and stress conditions.

    Stubben CJ, Micheva-Viteva SN, Shou Y, Buddenborg SK, Dunbar JM and Hong-Geller E

    BMC genomics 2014;15;385

  • Genomic diversity of Escherichia isolates from diverse habitats.

    Oh S, Buddenborg S, Yoder-Himes DR, Tiedje JM and Konstantinidis KT

    PloS one 2012;7;10;e47005

  • The in vivo transcriptome of Schistosoma mansoni in the prominent vector species Biomphalaria pfeifferi with supporting observations from Biomphalaria glabrata.

    Buddenborg SK, Kamel B, Hanelt B, Bu L, Zhang SM et al.

    PLoS neglected tropical diseases 2019;13;9;e0007013

  • Transcriptomic responses of Biomphalaria pfeifferi to Schistosoma mansoni: Investigation of a neglected African snail that supports more S. mansoni transmission than any other snail species.

    Buddenborg SK, Bu L, Zhang SM, Schilkey FD, Mkoji GM and Loker ES

    PLoS neglected tropical diseases 2017;11;10;e0005984

  • Whole genome analysis of a schistosomiasis-transmitting freshwater snail.

    Adema CM, Hillier LW, Jones CS, Loker ES, Knight M et al.

    Nature communications 2017;8;15451

  • Altered Gene Expression in the Schistosome-Transmitting Snail Biomphalaria glabrata following Exposure to Niclosamide, the Active Ingredient in the Widely Used Molluscicide Bayluscide.

    Zhang SM, Buddenborg SK, Adema CM, Sullivan JT and Loker ES

    PLoS neglected tropical diseases 2015;9;10;e0004131

  • Differential expression of small RNAs from Burkholderia thailandensis in response to varying environmental and stress conditions.

    Stubben CJ, Micheva-Viteva SN, Shou Y, Buddenborg SK, Dunbar JM and Hong-Geller E

    BMC genomics 2014;15;385

  • Genomic diversity of Escherichia isolates from diverse habitats.

    Oh S, Buddenborg S, Yoder-Himes DR, Tiedje JM and Konstantinidis KT

    PloS one 2012;7;10;e47005

Kay Buddenborg, Sarah
Sarah's Timeline
2018

PhD, Biology, University of New Mexico

Joined the Parasite Genomics group, Wellcome Sanger Institute

2008

B.S., Microbiology and Molecular Genetics, Michigan State University