UK scientific breakthrough to help animals worldwide

Getting a grip on the Strangles pathogen - leading UK scientific institutes publish new genome sequences

UK scientific breakthrough to help animals worldwide

equi_300.jpg
Schematic circular diagrams of the Streptococcus equi (top) and Streptococcus zooepidemicus genomes (bottom). Outer two circles are gene predictions: 11 concentric blue circles are matches with a series of species of streptococcus.

Research published today marks a further leap forward towards combating the plague of the horse world - Strangles - and other diseases of animals.

A consortium including the Animal Health Trust, the University of Cambridge and the Wellcome Trust Sanger Institute has solved the DNA sequences of Streptococcus equi - the causative agent of Strangles, and Streptococcus zooepidemicus, a versatile relative that causes a range of diseases in animals, including horses and dogs, and occasionally humans.

These DNA sequences shed new light on how these bacteria cause disease. They also highlight many new areas for developing better diagnostic tests, therapies and preventive vaccines.

"The publication of these genomes in PLoS Pathogens is the culmination of over seven years of research. We are extremely excited about their implications for future international research towards improving animal and human health."

Dr Andrew Waller, The Animal Health Trust's Head of Bacteriology

The research, funded by The Horse Trust and the Horserace Betting Levy Board (HBLB), has already enabled the AHT to develop DNA and blood tests to diagnose the horse disease, Strangles. It is now concentrating its efforts on developing safe and effective vaccines against Strangles and the many diseases caused by S. zooepidemicus.

"The news that the research we funded has not only resulted in reducing the distress caused by Strangles, but will now also help to prevent diseases in horses and other animals is brilliant. We're delighted to be involved in this world-leading scientific research, from which we are already seeing such positive results."

Brigadier Paul Jepson, The Horse Trust's Chief Executive​

"S. zooepidemicus causes a host of diseases in horses that affect their health and welfare. This research is an important contribution towards the prevention, diagnosis and treatment of inflammatory airway disease, upper respiratory disease and abortion in equines. Reducing the impact of S. zooepidemicus on the training, racing and breeding of Thoroughbreds will be a significant benefit to horseracing."

Professor Willie Donachie, Chairman of the Horserace Betting Levy Board's Veterinary Advisory Committee

S. equi evolved from S. zooepidemicus, which is usually harmless. However, S. zooepidemicus is opportunistic and can cause respiratory disease and abortion in horses, acute fatal haemorrhagic pneumonia in dogs and mastitis in cattle, goats and sheep.

Surprisingly, S. equi has, in its enhanced arsenal of biological weapons, genes that are very similar to those found in a type of Streptoccocus that causes pharyngitis, toxic shock syndrome, impetigo and scarlet fever in humans: the S. equi sequence will also help with those human studies.

"S. zooepidemicus and S. equi are brothers in arms who share a common ancestry but, while acquiring some genes, S. equi has been discarding others it no longer needs. The makings of this pathogen may very well be its undoing: it has lost functions found in its more versatile relatives, and consequently finds itself backed into a corner."

"With the new improved diagnostics, and the prospect of an effective vaccine round the corner, eradication becomes a real possibility."

Dr Matthew Holden, leader of the analysis team at the Wellcome Trust Sanger Institute ​

Notes to Editors
Publications
  • Genomic evidence for the evolution of Streptococcus equi: host restriction, increased virulence, and genetic exchange with human pathogens.

    Holden MT, Heather Z, Paillot R, Steward KF, Webb K et al.

    PLoS pathogens 2009;5;3;e1000346

Funding

This research was funded by the Horse Trust and the Horserace Betting Levy Board (HHLB)

Participating Centres
  • Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
  • Centre for Preventive Medicine, Animal Health Trust, Newmarket, Suffolk, United Kingdom
  • Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
  • The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, Oxford, United Kingdom
  • Institute for Cell and Molecular Biosciences, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
  • Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
Selected Websites
Contact the Press Office

Emily Mobley, Media Manager

Tel +44 (0)1223 496 851

Dr Samantha Wynne, Media Officer

Tel +44 (0)1223 492 368

Dr Matthew Midgley, Media Officer

Tel +44 (0)1223 494 856

Wellcome Sanger Institute,
Hinxton,
Cambridgeshire,
CB10 1SA,
UK

Mobile +44 (0) 7748 379849

Recent News

Researchers identify new possibilities for the treatment of inflammatory bowel disease
Two molecular pathways found to be integral to maintaining balance in the digestive system
Root of childhood kidney cancer discovered
Pre-cancerous signatures found in healthy tissue point the way towards new treatment options
From childhood cancer to mapping human development: Pioneering scientist awarded 2019 Foulkes Foundation medal
Congratulations to Professor Muzlifah Haniffa, who has been recognised for her work on the immune system and childhood cancer