News Archive

News Archive

Second Genetic Link to Weight and Obesity

Second Genetic Link to Weight and Obesity

New DNA variants found that can help to pile on the pounds

A study of 90,000 people has uncovered new genetic variants that influence fat mass, weight and risk of obesity. The variants act in addition to the recently described variants of the FTO gene: on average, adults carrying variants in both genes are 3.8 kg (or 8.5 lb) heavier.

Genome Campus has Top Two in the UK

Genome Campus has Top Two in the UK

Wellcome Trust Sanger Institute and European Bioinformatics Institute top list of most influential UK research

The impact of research reports from the Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute makes them the top two most influential research institutions in the UK, according to results published this week. In addition, nine of the top 25 most influential UK researchers are current or recent staff at the Wellcome Trust Genome Campus near Cambridge, UK, home to the two powerhouse institutes.

Seeing the enemy up close

Seeing the enemy up close

New-technology DNA sequencing boosts cancer genome research

A massive, new-technology DNA sequencing project has uncovered more than 100 novel rearrangements of the DNA of lung cancer cells. The study shows that new sequencing methods are able to capture these changes rapidly and to reveal changes that were not feasible using existing methods.

Global Genetics Consortium Sets Sights On Cancer

Global Genetics Consortium Sets Sights On Cancer

The International Cancer Genome Consortium

Researchers from four continents today announced the launch of the International Cancer Genome Consortium (ICGC), a major collaboration designed to identify the key genetic mutations involved in up to 50 types of cancer.

Largest ever study of genetics of common disease just got bigger

Largest ever study of genetics of common disease just got bigger

DNA samples from 120,000 people are to be analysed in a £30 million follow up to last year's Wellcome Trust Case Control Consortium (WTCCC), the largest ever study of the genetics behind common diseases. The seven-fold increase in the number of samples to be analysed will allow researchers to look at 25 diseases as well as studying the genetics of learning in children and individuals' responses to statins.

Researchers will examine between 500,000 and 1 million variants (SNPs) per sample as well as a comprehensive set of copy number variants (CNVs). Both SNPs and CNVs are responsible for the individual variation in our genomes.​

Crusader Y chromosomes in Lebanon

Crusader Y chromosomes in Lebanon

The most comprehensive genetic study yet on the world's ancient crossroads - Lebanon - reveals the legacies left by travellers to and invaders of Lebanon - showing that the Crusaders left chromosomes as well as castles. The results were obtained by a global team of Genographic scientists, led by Dr. Pierre Zalloua of Lebanese American University, Beirut and Dr. Chris Tyler-Smith of the Wellcome Trust Sanger Institute, Hinxton, near Cambridge, UK.

Lebanese Christian men are more likely to carry genetic signatures found in Europe - and thought to have been carried there by the Crusades; Lebanese Muslim men are more likely to carry genetic signatures deriving from the Muslim expansions of the 7th and 8th centuries. This is one of the few times that scientists have been able to relate distinct genetic patterns to well-documented population movements within a geographic region.

Novel method to reveal drug targets

Novel method to reveal drug targets

Interactions between proteins studied on a global scale

Wellcome Trust Sanger Institute scientists have developed a new large-scale method to identify the interactions between proteins that are a major target for therapeutic intervention. The novel method can identify the weak, short-lived interactions that are characteristic of cell responses to cues from the environment or from within the body.

Scientists reveal a new target to fight bad cholesterol

Scientists reveal a new target to fight bad cholesterol

Genetic link to levels of LDL cholesterol

Scientists have uncovered a new region in the genome that is responsible for the body's ability to regulate bad cholesterol which is linked to heart attack and stroke. Their findings are published in The Lancet.

International Consortium Announces the 1000 Genomes Project

International Consortium Announces the 1000 Genomes Project

Major sequencing effort will produce most detailed map of human genetic variation to support disease studies

An international research consortium today announced the 1000 Genomes Project, an ambitious effort that will involve sequencing the genomes of at least a thousand people from around the world to create the most detailed and medically useful picture to date of human genetic variation.

Taking Sequencing Forward

Taking Sequencing Forward

New Team to Lead DNA Sequencing at the Sanger Institute

The Wellcome Trust Sanger Institute has recently made a major investment in new DNA sequencing technology which will increase production 60-fold. The Institute today announces the appointment of a new senior management team to lead the Institute's efforts to generate DNA sequence data of value to its core programmes and to the wider biomedical research community.

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