A landmark genomic study, with contributors from over two-dozen countries, shows the current problem of antibiotic resistant typhoid is driven by a single clade, family of bacteria, called H58 that has now spread globally.
A study, published in Cell, demonstrates the power of organoids to capture, in three dimensions, the multiple mutations that occur in tumours. Organoids, small clusters of cells that accurately mimic the behaviour of human tissue, can be used to test cancer drugs and, eventually, to identify effective personalised treatments for patients.
A survey of nearly 7000 people has revealed that 98 per cent want to be informed if researchers using their genetic data stumble upon indicators of a serious preventable or treatable disease. The study, which comes after the Government's announcement that Genomics England will sequence 100,000 genomes by 2017, begins an important and on-going conversation about how our genomic data is used.
To combat antibiotic resistance, scientists need to understand the evolution of bacteria and examine this alongside the characteristics of the populations they infect, according to research published in The Lancet Infectious Diseases.
Researchers have developed a large-scale sequencing technique called Genome and Transcriptome Sequencing (G&T-seq) that reveals, simultaneously, the unique genome sequence of a single cell and the activity of genes within that single cell.
The first project to sequence whole genomes from mountain gorillas has given scientists and conservationists new insight into the impact of population decline on these critically endangered apes. While mountain gorillas are extensively inbred and at risk of extinction, research published today in Science finds more to be optimistic about in their genomes than expected.
In a study that overturns previous thinking about how human cancers spread, researchers have discovered that multiple cancerous cells can spread from a primary tumour in the prostate to the same new location in the body. The study recorded patterns of spread from primary prostate tumours to secondary tumours through a process called metastasis, which causes 90 per cent of cancer-related deaths.
The Wellcome Trust Sanger Institute is a partner organisation in a prospective Parliamentary All-party Group (APG) aimed at helping politicians to understand and realise the health benefits of UK investment and excellence in science and technology. The group plans to begin work after the General Election in May to ensure that NHS patients benefit fully from scientific advances.
The Basic Sciences Division of the Fred Hutchinson Cancer Research Centre in Seattle, US, awards the prize each year to celebrate outstanding achievement during graduate studies in the biological sciences. Dr Alexandrov, the only European recipient on this year's list, will present his influential paper 'Signatures of mutational processes in human cancer', published in Nature, at the centre's annual scientific symposium on 1 May 2015.
The Wellcome Genome Campus is marking International Women's Day 2015 by giving its first award for Best Practice in Supporting Women in Science. The recipients are Dr John Overington of EMBL-European Bioinformatics Institute (EMBL-EBI) and Ms Laura Huckins of the Wellcome Trust Sanger Institute.