News Archive - 2014

News Archive - 2014

Comparison holds key to human infection

Comparison holds key to human infection

Why humans don’t suffer from chimpanzee malaria

DNA region controlling red blood cell invasion holds genetic key to infection.

Samtools CRAMS in support for improved compression formats

Samtools CRAMS in support for improved compression formats

Key upgrade to genomics software will underpin global data sharing

Computer scientists at the Wellcome Trust Sanger Institute have released a major upgrade of Samtools, one of the most popular next-generation sequence analysis tools. The revised Samtools 1.0 enables researchers to easily compress, share and analyse genomic sequence data, reducing costs and supporting genomics research around the world.

Why do resistant bacteria succeed?

Why do resistant bacteria succeed?

New approach helps to understand how and why a disease emerges, even if it happened centuries ago

In two new studies, scientists use genome sequencing of worldwide samples to show that bacteria can take very different routes to becoming a successful disease. Researchers can use these large-scale approaches to track pathogen transmission patterns across the globe and therefore possibly to predict the emergence and spread of a new disease.

Finding the genetic culprits that drive antibiotic resistance

Finding the genetic culprits that drive antibiotic resistance

Genome-wide association study in disease-causing bacteria paves way for clinical tool

Researchers have developed a powerful new tool to identify genetic changes in disease-causing bacteria that are responsible for antibiotic resistance. The results from this technique could be used in clinics within the next decade to decide on the most effective treatments for diseases such as pneumonia and meningitis.

Mobile DNA elements restructure cancer genomes

Mobile DNA elements restructure cancer genomes

Hundreds of mutations in lung and colorectal cancers caused by previously overlooked mechanism

Researchers have found a novel mechanism that can restructure a cancer's genome and introduce hundreds of mutations. Previously overlooked through misidentification, this mechanism, a common feature of lung and colorectal cancers, raises questions about the effect environmental factors can have on the evolution of a tumour.

Genomics API supports Global Alliance for Genomics and Health

Genomics API supports Global Alliance for Genomics and Health

Global Alliance for Genomics and Health unveils new genomics API allowing for seamless sharing of genetic data

Alliance's Data Working Group develops Version 0.5 of genomics API to enable interoperability.

Genome Campus will host UK NHS 100,000 genomes project

Genome Campus will host UK NHS 100,000 genomes project

Sanger Institute and Wellcome Trust Genome Campus will host a £200 million project to sequence 100,000 NHS patients' genomes

Genomics England, a company created by the Department of Health, is partnering with commercial sequencing company Illumina to decipher the genetic codes of 100,000 people in the UK to investigate the genetics of cancer and rare genetic diseases. The work will be carried out in a £27 million sequencing centre that is being funded and built by the Wellcome Trust on its Genome Campus in Hinxton, near Cambridge.

Urban lifestyle risk factors increase in world's most rural area

Urban lifestyle risk factors increase in world's most rural area

Small increases in urbanicity in Uganda linked to cardiometabolic risk factors

Even in sub-Saharan Africa, the world's most rural region, urbanisation is associated with a higher prevalence of lifestyle risk factors, according to a new study. Within Ugandan communities that lack paved roads and running water, people living in villages with relatively more urban features were more likely to have risk factors for cardiometabolic diseases.

New malaria vaccine candidates identified

New malaria vaccine candidates identified

Previously untested antigens found in large-scale study of patients in Kenya

Researchers have discovered new vaccine targets that could help in the battle against malaria. Taking a new, large-scale approach to this search, researchers tested a library of proteins from the Plasmodium falciparum parasite with antibodies produced by the immune systems of a group of infected children.

New technique maps life's effects on our DNA

New technique maps life's effects on our DNA

The impact of our living conditions on the DNA of each of our cells can now be studied

Collaborators from the Wellcome Trust Sanger Institute-EBI Single Cell Genomics Centre and the BBSRC-funded Babraham Institute have developed a new approach that reveals how our environments affect our development and the traits we inherit from our parents.

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