News Archive - 2011

News Archive - 2011

Data centre shutdown for green power source upgrade

Data centre shutdown for green power source upgrade

On Friday 21 October 2011, the Wellcome Trust Sanger Institute will be taking its data centre offline from 12.30pm UK BST (11.30 UTC) until 11am UK BST (10.00 UTC) Monday 24 October

The switch-off, only the third since its commissioning in early 2005, is to allow a new greener and more sustainable power source to be attached to the data centre, helping to secure a long-term future of uninterrupted service for the worldwide research community.

Clean correction of a patient's genetic mutation

Clean correction of a patient's genetic mutation

New gene therapy methods accurately correct mutation in patient's stem cells, bringing personalized cell therapies one step closer

For the first time, scientists have cleanly corrected a human gene mutation in a patient's stem cells. The result, reported in Nature on Wednesday 12 October, brings the possibility of patient-specific therapies closer to becoming a reality.

Seeking superior stem cells

Seeking superior stem cells

New technique produces one hundred-fold increase in efficiency in reprogramming human cells

Researchers from the Wellcome Trust Sanger Institute have today (10/10/2011) announced a new technique to reprogramme human cells, such as skin cells, into stem cells. Their process increases the efficiency of cell reprogramming by one hundred-fold and generates cells of a higher quality at a faster rate.

Scientists identify cause of severe hypoglycaemia

Scientists identify cause of severe hypoglycaemia

Research provides the prospect of effective drug treatments for the genetic disorder

Cambridge scientists have identified the cause of a rare, life-threatening form of hypoglycaemia. Their findings, which have the potential to lead to pharmaceutical treatments for the disorder, were published today, 07 October, in the journal Science.

Cutting to the heart of swine genomics

Cutting to the heart of swine genomics

European SABRE project delivers suite of resources

An announcement on the completion of a pan-European project called SABRE (Cutting-Edge Genomics for Sustainable Animal Breeding) shows the huge value that EC-funded research projects can bring to the UK. The SABRE project has provided fundamental knowledge on genomics and epigenetics in pigs, chickens and cattle and the tools required to implement this knowledge in breeding programmes.

Genetic library will speed up disease research

Genetic library will speed up disease research

International consortium will reveal gene function from mouse genetics

An international project to create one of the largest libraries of mammalian genetic function data is launched on 29 September 2011. The International Mouse Phenotyping Consortium (IMPC) is building a library of mammalian gene function that will describe the function of every gene in the mouse genome.

Researchers uncover gene associated with blood cancers

Researchers uncover gene associated with blood cancers

New genetic insights could facilitate screening for mutation

A genomic study of chronic blood cancer - a precursor to leukaemia - has discovered gene mutations that could enable diagnosis using only a blood test, avoiding the need for an invasive and painful bone marrow biopsy.

Researchers develop mouse genetic blueprint

Researchers develop mouse genetic blueprint

Mouse study drives forward understanding of human biology

Researchers have developed a valuable mouse genetic blueprint that will accelerate future research and understanding of human genetics. The international team, led by researchers at the Wellcome Trust Sanger Institute and the University of Oxford, explain in two papers published in Nature on 14 September 2011 how they decoded and compared the genome sequence of 17 mouse strains.

New biochemical discoveries into developing disease

New biochemical discoveries into developing disease

Study of metabolites reveals health implications from small molecules

Researchers have undertaken the most comprehensive investigation of genetic variance in human metabolism and discovered new insights into a range of common diseases. Their work has revealed 37 new variants that are associated with concentrations of metabolites in the blood. Many of these match variants associated with diseases such as chronic kidney disease, type 2 diabetes and blood clotting.

Third genetic link to osteoarthritis discovered

Third genetic link to osteoarthritis discovered

New gene identified that affects risk of osteoarthritis following use of 1000 Genomes study data

Researchers have today revealed a new gene associated with osteoarthritis. This is only the third gene to be identified for this painful and debilitating disease that affects more than 40 per cent of people aged more than 70 years.

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