News Archive - 2010

News Archive - 2010

Professor Leena Peltonen-Palotie: 1952-2010

Professor Leena Peltonen-Palotie: 1952-2010

Professor Leena Peltonen-Palotie, Head of Human Genetics at the Wellcome Trust Sanger Institute passed away on 11 March 2010 at her home in Finland after a long and characteristically courageous battle with cancer. She was 57.

Leena was a leading human geneticist of her era, holding at her death appointments at the Wellcome Trust Sanger Institute, the Institute for Molecular Medicine Finland and the Broad Institute, Cambridge, USA. In the past six months, she was honoured with the Carter medal from the Clinical Genetics Society for her outstanding contribution to clinical genetics and recognition as Academician of Science, the highest honour in her home country.

Exploring genetic effects in cells

Exploring genetic effects in cells

A deep look into population variation in gene activity provides key insight to cell functions and disease susceptibility

Researchers report the most extensive and comprehensive study of the impact of genetic variations on gene activity. The study uses RNA sequencing at an unprecedented resolution to reveal genetic effects in cellular processes.

Sorting the drivers from the passengers in the cancer genome

Sorting the drivers from the passengers in the cancer genome

Screening cancer genomes for the driver mutations in tumour suppressor genes

A new study of mutations in cancer genomes shows how researchers can begin to distinguish the 'driver' mutations that push cells towards cancer from the 'passenger' mutations that are a by-product of cancer cell development. The study also shows that at least one in nine genes can be removed without killing human cells.

Gentlemen or farmers?

Gentlemen or farmers?

Most modern European males descend from farmers who migrated from the Near East

A new study has found that most men in Europe descend from the first farmers who migrated from the Near East 10,000 years ago. The findings were published in the open-access journal PLoS Biology.

Tracking MRSA evolution and transmission

Tracking MRSA evolution and transmission

Revolutionary strategy for control and prevention of infection

For the first time, researchers have shown how transmission of MRSA from one person to another can be precisely tracked in a hospital setting. The team have developed a remarkable new method that can 'zoom' from large-scale inter-continental transmission events to the much finer detail of person-to-person infection of MRSA within a single hospital.

From biological basics to diabetes discovery

From biological basics to diabetes discovery

Researchers uncover novel genetic markers for diabetes-related traits

In two major studies published in Nature Genetics today, researchers use biological understanding to dissect the genetics of diabetes. An international team comprising researchers from more than 100 institutions analysed vast suites of genetic data from more than 100,000 people of European descent to uncover the associations.

Unravelling kidney cancer

Unravelling kidney cancer

Mutations in the genome regulation machinery identified in clear cell renal cell carcinoma

In a new study, scientists have searched for mutations in the gene regions of more than 100 kidney cancer samples, the largest number of samples from a single tumour type to be sequenced to date.

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