Human Cell Atlas Group

Cellular Genetics

The International Human Cell Atlas initiative aims to create comprehensive reference maps of all human cells—the fundamental units of life—as a basis for both understanding human health and diagnosing, monitoring, and treating disease. We are undertaking research to develop, optimise and assess the performance of key enabling experimental and computational technologies that will underly this large international effort. We are also working to generate data from pilot projects that will begin to form the first draft of the Atlas. We work in collaboration with research groups within the Wellcome Sanger Institute as well as in EMBL-EBI on the Hinxton Campus.

Our work will involve single cell analysis of tissues at an unprecedented scale and involve research and medical institutes throughout the world. A successful Atlas will require optimised, scalable experimental protocols as well as computational approaches that can integrate a large amount of diverse data. The Human Cell Atlas team within the Wellcome Sanger Institute is working to develop and understand technologies that will enable the successful generation of an atlas. We are coordinating HCA-focused research efforts throughout the Genome Campus. We are using single-cell transcriptomics methods to analyse the gene expression in thousands of individual cells. These data are then processed using novel and sophisticated computational approaches to assign them particular cell types and to allow datasets to be compared across multiple locations and experimental procedures.

Core team

Photo of Lira Mamanova

Lira Mamanova

Scientific Manager

Photo of Krzysztof Polanski

Krzysztof Polanski

Computational Biologist

Photo of Tracey Andrew

Tracey Andrew

Executive Administrator Human Cell Atlas

Partners

We work with the following groups

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The HCA Developmental Seminar Series is continuing. On July 24th, the focus will be on Spatial Cell Mapping, with Speakers Ali Ertürk and Mats Nilsson. More information to come soon on

HCA Meetings

www.humancellatlas.org