Human Cell Atlas Group
The International Human Cell Atlas initiative aims to create comprehensive reference maps of all human cells—the fundamental units of life—as a basis for both understanding human health and diagnosing, monitoring, and treating disease. We are undertaking research to develop, optimise and assess the performance of key enabling experimental and computational technologies that will underly this large international effort. We are also working to generate data from pilot projects that will begin to form the first draft of the Atlas. We work in collaboration with research groups within the Wellcome Sanger Institute as well as in EMBL-EBI on the Hinxton Campus.
Our work will involve single cell analysis of tissues at an unprecedented scale and involve research and medical institutes throughout the world. A successful Atlas will require optimised, scalable experimental protocols as well as computational approaches that can integrate a large amount of diverse data. The Human Cell Atlas team within the Wellcome Sanger Institute is working to develop and understand technologies that will enable the successful generation of an atlas. We are coordinating HCA-focused research efforts throughout the Genome Campus. We are using single-cell transcriptomics methods to analyse the gene expression in thousands of individual cells. These data are then processed using novel and sophisticated computational approaches to assign them particular cell types and to allow datasets to be compared across multiple locations and experimental procedures.
Dr Kerstin Meyer
Principal Staff Scientist
Kerstin Meyer is a principal staff scientist in cellular genetics, working with the Teichmann group and leading Human Cell Atlas projects within the Sanger Institute. Kerstin is using her expertise in molecular biology and transcriptional regulation of gene expression to lead extended pilot studies for data generation for the Human Cell Atlas.
Function of human DNA and its variation
Our goal is to understand how genetic background influences outcome of mutations. To do so, we measure, model, and modulate cell ...