Wellcome Sanger Institute
Gene Editing and Cellular Research and Development
Cellular Operations
We develop novel genome editing techniques, cellular differentiation and cellular phenotyping systems, especially with respect to high-throughput investigation of gene and non-coding regulatory element function.
- Developing induced pluripotent stem cell models of genetic disease
- Genetic screening techniques using pooled and arrayed CRISPR/Cas9
- Differentiation protocols of pluripotent stem cells to brain and blood-derived lineages
- Application of screening to complex phenotypic readouts such as single cell transcriptomics or spatial genomics
We develop novel cutting-edge CRISPR screening techniques such as saturation mutagenesis, base editing, dual guide libraries and CRISPRa/i and couple these to complex phenotypic readouts such as single cell transcriptomics, spatial genomics or phenotypic assays of cellular function. We also work with and develop human cellular systems and differentiation protocols of iPSCs in both 2D and 3D to better model human disease states in vitro. The systems developed will be applied to probe the genetic basis of cellular function in health and disease and understand the underlying cell biology.
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[excerpt] => We develop novel genome editing techniques, cellular differentiation and cellular phenotyping systems, especially with respect to high-throughput investigation of gene and non-coding regulatory element function.
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[post_excerpt] => In collaboration with our colleagues in Cellular Operations and Stem Cell Informatics, our work focuses on supporting and delivering the gene <span title="... editing requirements of the Institute's faculty and research programmes. Through the adoption and implementation of modern genome editing techniques, we tailor our technical experience to help answer biological questions. We optimise, develop and democratise the delivery of genome editing tools and platforms for the Institute’s research programmes. For our collaborating partners we provide an agile, project focused, cost effective and efficient service as well as develop and provide biological resources, technical support and training for research groups and their staff.">...</span>
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[introduction] => <p><span><span><span>We develop novel genome editing techniques, cellular differentiation and cellular phenotyping systems, especially with respect to high-throughput investigation of gene and non-coding regulatory element function. </span></span></span></p> <ul> <li>Developing induced pluripotent stem cell models of genetic disease</li> <li>Genetic screening techniques using pooled and arrayed CRISPR/Cas9</li> <li>Differentiation protocols of pluripotent stem cells to brain and blood-derived lineages</li> <li>Application of screening to complex phenotypic readouts such as single cell transcriptomics or spatial genomics </li> </ul>
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[post_title] => Cancer Dependency Map
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[content] => <p>We develop novel cutting-edge CRISPR screening techniques such as saturation mutagenesis, base editing, dual guide libraries and CRISPRa/i and couple these to complex phenotypic readouts such as single cell transcriptomics, spatial genomics or phenotypic assays of cellular function. We also work with and develop human cellular systems and differentiation protocols of iPSCs in both 2D and 3D to better model human disease states <i>in vitro</i>. The systems developed will be applied to probe the genetic basis of cellular function in health and disease and understand the underlying cell biology.</p>
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[post_title] => Gene Editing and Cellular Research and Development
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[post_excerpt] => Our goal is to understand how genetic background influences outcome of mutations. To do so, we measure, model, and modulate cell <span title="... state across healthy and disease-relevant human genetic diversity. In the lab, we develop tools for genetic perturbations, and use genome engineering and synthetic biology to create cell lines for screening cellular traits. In the office, we develop probabilistic models as well as software tools to accurately and efficiently analyse the readouts.">...</span>
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Core team
Thomas Burgold
Staff Scientist
Dr Sarah Cooper
Senior Staff Scientist
Dr Qianxin Wu
Staff Scientist
Dr Erica Bello
Postdoctoral Fellow
Previous team members
Dr Daniel Gitterman
Staff Scientist
Related groups
Wellcome Sanger Institute
Partners
We work with the following groups
External
OpenTargets
Open Targets is an innovative, large-scale, multi-year, public-private partnership that uses human genetics and genomics data for systematic drug target identification and prioritisation.
Publications
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