Wellcome Sanger Institute

Gene Editing and Cellular Research and Development

Cellular Operations

We develop novel genome editing techniques, cellular differentiation and cellular phenotyping systems, especially with respect to high-throughput investigation of gene and non-coding regulatory element function. 

  • Developing induced pluripotent stem cell models of genetic disease
  • Genetic screening techniques using pooled and arrayed CRISPR/Cas9
  • Differentiation protocols of pluripotent stem cells to brain and blood-derived lineages
  • Application of screening to complex phenotypic readouts such as single cell transcriptomics or spatial genomics 

We develop novel cutting-edge CRISPR screening techniques such as saturation mutagenesis, base editing, dual guide libraries and CRISPRa/i and couple these to complex phenotypic readouts such as single cell transcriptomics, spatial genomics or phenotypic assays of cellular function. We also work with and develop human cellular systems and differentiation protocols of iPSCs in both 2D and 3D to better model human disease states in vitro. The systems developed will be applied to probe the genetic basis of cellular function in health and disease and understand the underlying cell biology.

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                            [post_title] => Cooper, Sarah
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                            [post_title] => Wu, Qianxin
                            [post_excerpt] => Qianxin is interested in the functional of noncoding genome. She is fascinated by how hundreds and thousands of morphologically and functionally&nbsp;<span title="... distinct cell types are being generated from the same genetic material. Qianxin is also passionate about developing novel biotechnology to answer the fundamental question of gene regulation.">...</span>
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    [excerpt] => We develop novel genome editing techniques, cellular differentiation and cellular phenotyping systems, especially with respect to high-throughput investigation of gene and non-coding regulatory element function.
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                            [post_title] => Bassett, Andrew
                            [post_excerpt] => Andrew leads the Human Gene Editing R&amp;D group at the Wellcome Sanger Institute.
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                            [post_title] => Adams Group
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                            [post_title] => Gene Editing
                            [post_excerpt] => In collaboration with our colleagues in Cellular Operations and Stem Cell Informatics, our work focuses on supporting and delivering the gene&nbsp;<span title="... editing requirements of the Institute's faculty and research programmes. Through the adoption and implementation of modern genome editing techniques, we tailor our technical experience to help answer biological questions. We optimise, develop and democratise the delivery of genome editing tools and platforms for the Institute&rsquo;s research programmes. For our collaborating partners we provide an agile, project focused, cost effective and efficient service as well as develop and provide biological resources, technical support and training for research groups and their staff.">...</span>
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                            [post_title] => Garnett Group
                            [post_excerpt] => The Translational Cancer Genomics team investigate how genetic alterations in cancer contribute to disease and impact on response to therapy.
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                            [post_excerpt] => Our goal is to understand how genetic background influences outcome of mutations. To do so, we measure, model, and modulate cell&nbsp;<span title="... state across healthy and disease-relevant human genetic diversity. In the lab, we develop tools for genetic perturbations, and use genome engineering and synthetic biology to create cell lines for screening cellular traits. In the office, we develop probabilistic models as well as software tools to accurately and efficiently analyse the readouts.">...</span>
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    [introduction] => <p><span><span><span>We develop novel genome editing techniques, cellular differentiation and cellular phenotyping systems, especially with respect to high-throughput investigation of gene and non-coding regulatory element function. </span></span></span></p> <ul> <li>Developing induced pluripotent stem cell models of genetic disease</li> <li>Genetic screening techniques using pooled and arrayed CRISPR/Cas9</li> <li>Differentiation protocols of pluripotent stem cells to brain and blood-derived lineages</li> <li>Application of screening to complex phenotypic readouts such as single cell transcriptomics or spatial genomics </li> </ul>
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                            [post_title] => Cellular Operations
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                            [post_excerpt] => Open Targets is an innovative, public-private partnership that uses human genetics and genomics data at large scale for systematic drug target&nbsp;<span title="... identification and prioritisation.">...</span>
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                            [post_title] => Cancer Dependency Map
                            [post_excerpt] => The Cancer Dependency Map integrates the work of multiple experimental and computational research project at the Sanger Institute with the <span title="... shared aim of identifying dependencies in cancer cells which could be exploited to develop new therapies. This knowledge is foundational for our understanding of cancer biology and the development of precision cancer medicine.">...</span>
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                            [post_excerpt] => Hundreds of induced pluripotent stem cell lines for cellular genetic analysis
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    [research_introduction] => 
    [secondary_title] => Cellular Operations
    [slideshow] => 
    [title] => Gene Editing and Cellular Research and Development
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                                    [post_title] => Schwartzentruber, Jeremy
                                    [post_excerpt] => I am interested in advancing our understanding of how human genetic variation leads to differences between people in disease risk <span title="... and other traits. One of my major projects is to integrate multiple types of data - epigenetic, gene expression, conservation, etc. - to better predict which genetic variants affect gene regulation.">...</span>
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                                    [post_title] => Von Schiller, Dominique
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                                    [post_title] => Byrne, Meg
                                    [post_excerpt] => I am using CRISPR-Cas technologies to modify targeted loci in iPS cells for use in studying disease.
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                                    [post_title] => Burgold, Thomas
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                                    [post_content] => 
                                    [post_title] => Cooper, Sarah
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                                    [post_content] => 
                                    [post_title] => Wu, Qianxin
                                    [post_excerpt] => Qianxin is interested in the functional of noncoding genome. She is fascinated by how hundreds and thousands of morphologically and functionally&nbsp;<span title="... distinct cell types are being generated from the same genetic material. Qianxin is also passionate about developing novel biotechnology to answer the fundamental question of gene regulation.">...</span>
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                                    [post_title] => Bello, Erica
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                    [content] => <p>We develop novel cutting-edge CRISPR screening techniques such as saturation mutagenesis, base editing, dual guide libraries and CRISPRa/i and couple these to complex phenotypic readouts such as single cell transcriptomics, spatial genomics or phenotypic assays of cellular function. We also work with and develop human cellular systems and differentiation protocols of iPSCs in both 2D and 3D to better model human disease states <i>in vitro</i>. The systems developed will be applied to probe the genetic basis of cellular function in health and disease and understand the underlying cell biology.</p>
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    [ID] => 205739
    [page_url] => https://www.sanger.ac.uk/group/gene-editing-and-cellular-research-and-development/
    [page_title] => Gene Editing and Cellular Research and Development
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    [post_url] => https://www.sanger.ac.uk/group/gene-editing-and-cellular-research-and-development/
    [post_title] => Gene Editing and Cellular Research and Development
    [post_content] => 
    [post_status] => publish
    [created_at] => 2019-03-05 14:30:05
    [updated_at] => 2020-09-09 07:44:45
    [custom_credit] => Wellcome Sanger Institute
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                            [post_title] => Adams Group
                            [post_excerpt] => We are a team of cancer biologists, geneticists and computational biologists interested in understanding how cancers develop and the ways of&nbsp;<span title="... controlling their growth. We work on a range of malignancies but are particularly interested in melanoma and other skin cancers.">...</span>
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                            [post_title] => Gene Editing
                            [post_excerpt] => In collaboration with our colleagues in Cellular Operations and Stem Cell Informatics, our work focuses on supporting and delivering the gene&nbsp;<span title="... editing requirements of the Institute's faculty and research programmes. Through the adoption and implementation of modern genome editing techniques, we tailor our technical experience to help answer biological questions. We optimise, develop and democratise the delivery of genome editing tools and platforms for the Institute&rsquo;s research programmes. For our collaborating partners we provide an agile, project focused, cost effective and efficient service as well as develop and provide biological resources, technical support and training for research groups and their staff.">...</span>
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                            [post_title] => Garnett Group
                            [post_excerpt] => The Translational Cancer Genomics team investigate how genetic alterations in cancer contribute to disease and impact on response to therapy.
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                            [post_title] => Parts Group
                            [post_excerpt] => Our goal is to understand how genetic background influences outcome of mutations. To do so, we measure, model, and modulate cell&nbsp;<span title="... state across healthy and disease-relevant human genetic diversity. In the lab, we develop tools for genetic perturbations, and use genome engineering and synthetic biology to create cell lines for screening cellular traits. In the office, we develop probabilistic models as well as software tools to accurately and efficiently analyse the readouts.">...</span>
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Core team

Photo of Thomas Burgold

Thomas Burgold

Staff Scientist

Photo of Dr Sarah Cooper

Dr Sarah Cooper

Senior Staff Scientist

Photo of Dr Qianxin Wu

Dr Qianxin Wu

Staff Scientist

Photo of Dr Erica Bello

Dr Erica Bello

Postdoctoral Fellow

Previous team members

Photo of Dr Daniel Gitterman

Dr Daniel Gitterman

Staff Scientist

Partners

We work with the following groups

External

OpenTargets

Open Targets is an innovative, large-scale, multi-year, public-private partnership that uses human genetics and genomics data for systematic drug target identification and prioritisation.

 

Publications

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