Predicted Targets of mmu-miR-291a-3p Based on Experimental Evidence
Illumina Probe IDs | Gene Symbols | Gene Name | Entrez ID | Log Fold Change upon Dgcr8 Depletion | P-value of change upon Dgcr8 Depletion | Log Fold Change upon miR-291a-3p Reintroduction | P-value of change upon miR-291a-3p Reintroduction | GO Terms | KEGG Pathways | Transcript used for 3'UTR seed counts | 6mer(3)-AGCACT | 6mer(1A)-CACTTA | 6mer(2)-GCACTT | 7mer(2)(m8)-AGCACTT | 7mer(1A)-GCACTTA | 8mer(1A)-AGCACTTA | Target Scan Conserved Target Context Score | Target Scan Non-conserved Target Context Score | miRBase Targets P-value
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Nbi0eo.u_ToKS39e_w | Hp1bp3 | heterochromatin protein 1, binding protein 3 | 15441 | 1.47 | 2.9e-21 | 0.65 | 6.4e-05 | nucleosome assembly(GO:0006334) |  | OTTMUST00000023193 | 3 | 3 | 3 | 1 | 3 | 1 | Not Found | -0.2342 | Not Found
HKTHleDlfk2_w4k118 | Dctn4 | dynactin 4 | 67665 | 1.10 | 5.8e-21 | 0.92 | 1.0e-05 |  |  | ENSMUST00000025505 | 1 | 0 | 4 | 1 | 0 | 0 | Not Found | -0.208 | Not Found
xXFXjz.RJjJIk16QSo | Arhgef18 | rho/rac guanine nucleotide exchange factor (GEF) 18 | 102098 | 1.20 | 2.6e-19 | 0.56 | 1.9e-05 | actin cytoskeleton organization and biogenesis(GO:0030036) | small GTPase mediated signal transduction(GO:0007264) | regulation of cell shape(GO:0008360) | regulation of Rho protein signal transduction(GO:0035023) |  | OTTMUST00000076126 | 2 | 0 | 2 | 1 | 0 | 0 | -0.1761 | Not Found | Not Found
Zsu87Je6Dg9d9Vei1I | Chic1 * |  | 12212* | 1.24 | 2.2e-18 | 0.67 | 1.0e-05 |  |  | OTTMUST00000044104 | 4 | 5 | 5 | 1 | 1 | 0 | Not Found | -0.1875 | Not Found
3uBv_Ub24UCMUp76E4 | Tmem87b | transmembrane protein 87B | 72477 | 0.67 | 1.3e-17 | 0.71 | 1.2e-05 |  |  | OTTMUST00000036395 | 3 | 0 | 3 | 1 | 0 | 0 | Not Found | -0.1248 | Not Found
6SVCgVf5yvkUr3.d5E | Mgat4a | mannoside acetylglucosaminyltransferase 4, isoenzyme A | 269181 | 0.66 | 1.6e-17 | 0.48 | 2.5e-05 | carbohydrate metabolic process(GO:0005975) | N-Glycan biosynthesis(00510) | Glycan structures - biosynthesis 1(01030) |  |  |  |  |  |  |  | Not Found | -0.4217 | Not Found
KFiKoeh3SlfxL7deS8 | Tbcel | tubulin folding cofactor E-like | 272589 | 0.79 | 1.4e-15 | 0.66 | 1.4e-06 | protein modification process(GO:0006464) |  | ENSMUST00000066148 | 2 | 1 | 3 | 1 | 0 | 0 | Not Found | Not Found | Not Found
Ej5ewT_J98eO7nrqEo | Whsc1l1 | Wolf-Hirschhorn syndrome candidate 1-like 1 (human) | 234135 | 0.66 | 3.9e-15 | 0.54 | 3.1e-05 | transcription(GO:0006350) | regulation of transcription, DNA-dependent(GO:0006355) | chromatin modification(GO:0016568) |  | ENSMUST00000084026 | 7 | 2 | 7 | 5 | 2 | 1 | Not Found | -0.1427 | 0.00112896
rKeJNVhH4qQBK_U9ck | Gnb5 | guanine nucleotide binding protein (G protein), beta 5 | 14697 | 0.54 | 7.0e-15 | 0.69 | 2.1e-06 | signal transduction(GO:0007165) | G-protein coupled receptor protein signaling pathway(GO:0007186) |  | ENSMUST00000076889 | 1 | 0 | 2 | 1 | 0 | 0 | -0.1571 | Not Found | Not Found
BXu_5I6pSBRyHJJf14 | D030056L22Rik | RIKEN cDNA D030056L22 gene | 225995 | 0.62 | 9.7e-15 | 0.50 | 8.7e-06 |  |  | ENSMUST00000062753 | 1 | 0 | 2 | 1 | 0 | 0 | Not Found | -0.2362 | Not Found
QXS1Ku6d7erks5LTug |  |  |  | 0.73 | 3.1e-14 | 0.76 | 1.3e-05 |  |  |  |  |  |  |  |  |  |  |  |
Holi8e.uF76nVr.e.E | Tor1b | torsin family 1, member B | 30934 | 0.56 | 3.9e-14 | 0.52 | 2.9e-05 | biological_process(GO:0008150) | chaperone cofactor-dependent protein folding(GO:0051085) |  | OTTMUST00000027995 | 3 | 1 | 2 | 2 | 0 | 0 | Not Found | -0.1008 | Not Found
oyM1RN1xu0tf7Xiges | Il7 | interleukin 7 | 16196 | 0.67 | 3.0e-12 | 0.74 | 1.0e-06 | T cell lineage commitment(GO:0002360) | anti-apoptosis(GO:0006916) | immune response(GO:0006955) | regulation of gene expression(GO:0010468) | positive regulation of B cell proliferation(GO:0030890) | negative regulation of apoptosis(GO:0043066) | negative regulation of catalytic activity(GO:0043086) | bone resorption(GO:0045453) | positive regulation of T cell differentiation(GO:0045582) | positive regulation of organ growth(GO:0046622) | homeostasis of number of cells within a tissue(GO:0048873) | Cytokine-cytokine receptor interaction(04060) | Jak-STAT signaling pathway(04630) | Hematopoietic cell lineage(04640) |  |  |  |  |  |  |  | Not Found | -0.2369 | Not Found
Nf_4d307578y3pW6oQ | Bat5 | HLA-B associated transcript 5 | 193742 | 0.65 | 4.6e-12 | 0.52 | 2.8e-06 |  |  | ENSMUSESTT00000055410 | 2 | 1 | 2 | 2 | 1 | 1 | Not Found | -0.3073 | 0.00226352
KeR.j_.XBL3vV15.j8 | E2f1 | E2F transcription factor 1 | 13555 | 0.73 | 5.0e-12 | 0.49 | 3.2e-05 | regulation of cell cycle(GO:0051726) | apoptosis(GO:0006915) | transcription(GO:0006350) | regulation of transcription, DNA-dependent(GO:0006355) | cell cycle(GO:0007049) | forebrain development(GO:0030900) | regulation of transcription(GO:0045449) | positive regulation of transcription, DNA-dependent(GO:0045893) | positive regulation of transcription from RNA polymerase II promoter(GO:0045944) | Cell cycle(04110) | Pancreatic cancer(05212) | Glioma(05214) | Prostate cancer(05215) | Melanoma(05218) | Bladder cancer(05219) | Chronic myeloid leukemia(05220) | Small cell lung cancer(05222) | Non-small cell lung cancer(05223) | OTTMUST00000037809 | 1 | 0 | 2 | 0 | 0 | 0 | Not Found | Not Found | Not Found
3uKIKTKCuIcniH3tOk | Bicd2 | bicaudal D homolog 2 (Drosophila) | 76895 | 0.63 | 9.8e-12 | 0.49 | 2.0e-05 | microtubule-based movement(GO:0007018) |  | ENSMUST00000048544 | 1 | 2 | 3 | 1 | 0 | 0 | Not Found | Not Found | Not Found
6YOkcXyoT3LPn3Pv6k | Pfn2 | profilin 2 | 18645 | 1.00 | 6.8e-11 | 0.72 | 7.1e-05 | actin cytoskeleton organization and biogenesis(GO:0030036) | cytoskeleton organization and biogenesis(GO:0007010) | Regulation of actin cytoskeleton(04810) | OTTMUST00000065997 | 1 | 0 | 4 | 1 | 0 | 0 | -0.1369 | Not Found | Not Found
QPvVV.Lwb_seLc3E4I | Cep170 | centrosomal protein 170 | 545389 | 0.56 | 6.0e-10 | 0.57 | 1.1e-05 |  |  | ENSMUST00000057037 |  |  |  |  |  |  | Not Found | Not Found | Not Found
Nn_v556__f6DXtLhVc |  |  |  | 0.43 | 1.8e-09 | 0.79 | 4.2e-06 |  |  |  |  |  |  |  |  |  |  |  |
xT8NPGkl.aPjFXE9.8 | Entpd7 | ectonucleoside triphosphate diphosphohydrolase 7 | 93685 | 0.58 | 3.8e-09 | 0.65 | 3.5e-06 | ribonucleoside diphosphate catabolic process(GO:0009191) | ribonucleoside triphosphate catabolic process(GO:0009203) | Starch and sucrose metabolism(00500) | Folate biosynthesis(00790) | OTTMUST00000065276 | 1 | 1 | 1 | 1 | 1 | 1 | Not Found | Not Found | Not Found
9o66jF5AB7up_TI4c4 | Rab11a | RAB11a, member RAS oncogene family | 53869 | 0.46 | 1.6e-08 | 0.52 | 4.7e-06 | transport(GO:0006810) | small GTPase mediated signal transduction(GO:0007264) | protein transport(GO:0015031) |  |  |  |  |  |  |  |  | -0.3858 | Not Found | Not Found
QKBEi8HyKHlp5q5K1I | Ifi35 | interferon-induced protein 35 | 70110 | 0.28 | 4.7e-08 | 0.39 | 2.1e-05 |  |  | OTTMUST00000005867 | 1 | 2 | 1 | 1 | 1 | 1 | Not Found | Not Found | Not Found
xekoCDuV.HExea3S_c | Tnfaip1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | 21927 | 0.34 | 2.6e-07 | 0.90 | 6.0e-05 | potassium ion transport(GO:0006813) | embryonic development(GO:0009790) |  | OTTMUST00000000462 | 2 | 0 | 2 | 2 | 0 | 0 | -0.2121 | Not Found | Not Found
o6cIXSzdUskffej_D0 | 4933434E20Rik * |  | 99650* | 0.51 | 8.2e-06 | 0.65 | 1.1e-06 |  |  | ENSMUST00000068798 | 2 | 0 | 2 | 1 | 0 | 0 | Not Found | -0.2088 | Not Found
lq_eOfCErKvp0e8E5I | Zbtb41 | zinc finger and BTB domain containing 41 homolog | 226470 | 0.20 | 3.3e-05 | 0.68 | 4.5e-05 | transcription(GO:0006350) | regulation of transcription, DNA-dependent(GO:0006355) |  | OTTMUST00000051928 | 4 | 5 | 5 | 3 | 2 | 2 | -0.2492 | Not Found | Not Found
6X9TfVN8x7_f_OKfqo |  |  |  | 0.42 | 1.1e-04 | 0.38 | 6.5e-05 |  |  |  |  |  |  |  |  |  |  |  |
ltnt_R3rt4ml4I9Vq4 | Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 12575 | 0.68 | 5.0e-04 | 0.94 | 2.6e-05 | regulation of cell cycle(GO:0051726) | response to DNA damage stimulus(GO:0006974) | cell cycle(GO:0007049) | cell cycle arrest(GO:0007050) | negative regulation of cell proliferation(GO:0008285) | response to UV(GO:0009411) | positive regulation of B cell proliferation(GO:0030890) | negative regulation of apoptosis(GO:0043066) | positive regulation of non-apoptotic programmed cell death(GO:0043071) | negative regulation of cyclin-dependent protein kinase activity(GO:0045736) | ErbB signaling pathway(04012) | Cell cycle(04110) | p53 signaling pathway(04115) | Glioma(05214) | Prostate cancer(05215) | Melanoma(05218) | Bladder cancer(05219) | Chronic myeloid leukemia(05220) | OTTMUST00000078425 | 2 | 1 | 3 | 2 | 1 | 1 | Not Found | -0.3089 | Not Found
ud77jUnSmu2p_f.gcM | Gtf3c2 | general transcription factor IIIC, polypeptide 2, beta | 71752 | 0.18 | 1.8e-03 | 0.58 | 5.5e-06 | transcription(GO:0006350) |  | OTTMUST00000053730 | 4 | 1 | 2 | 2 | 1 | 1 | Not Found | -0.1006 | Not Found