M. africanum

The Sanger Institute is sequencing the genome of Mycobacterium africanum strain GM041182 (from labnumber 2004/01182), which has been deposited in the NCTC collection, in collaboration with Dr. Bouke de Jong, Dr. Richard Adegbola, Dr. Martin Antonio, Dr. Philip Hill, Dr Roger Brookes and Dr. Jacob Otu at the Bacterial Diseases Programme, MRC Laboratories, The Gambia and Prof. Mike Barer, Department of Infection, Immunity and Inflammation, University of Leicester.

M. africanum is a major cause of pulmonary tuberculosis in man in sub-Saharan Africa.

Shotgun sequencing is complete, and a database of reads is available for searching on our Blast Server, or for download from our FTP site.

There are 98,693 reads totalling 48.893 Mb and giving a theoretical coverage of 99.99% of the genome.

The genome is now finished and the finished genome is available in the same way.

The genome 4,389,314 bp with a G+C content of 65.58%

Assembly warning

Please note that the assembly database consists of unedited automatic assemblies; it will contain errors and misassemblies, along with E. coli and vector contamination. The contig numbers are not stable, and will vary with each data release. The sequences in the shotgun database are single reads from ABI sequencers; they will contain errors, along with both E. coli and vector contamination.

Data Release Statement

This sequencing centre plans on publishing the completed and annotated sequences in a peer-reviewed journal as soon as possible. Permission of the principal investigator should be obtained before publishing analyses of the sequence/open reading frames/genes on a chromosome or genome scale.

Sequencing enquiries

Please address all sequencing enquiries to: parkhill@sanger.ac.uk

webmaster@sanger.ac.uk

Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK Tel:+44 (0)1223 834244

Last Modified Wed Feb 18 10:35:13 2009

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