This calculator is intended as an adjunct to the paper and for research purposes only.
It has not been prospectively validated.
Data regarding the accuracy of the model are provided in the publication. In general, predictions are accurate in approximately 80% of cases.
To generate individual patient prognostic predictions:
First select the diagnosis of interest: ET, PV, MF or other (MPNu, MDS/MPN overlap, etc).
Then choose between:
Outcome predictions are from diagnosis and assume that all input parameters are present at diagnosis. If the time of genomic sampling is post diagnosis then we suggest adjusting patient age to time of genomic sampling, and to use this as the starting time for predictions.
The Genomics tab allows the user to view the frequency of mutations(s) across MPN subtypes.
Please address clinical queries to Dr Jyoti Nangalia or Dr Jacob Grinfeld.
Please address technical queries related to the web site and the app functionality to Dr Eugene Nadezhdin or Dr Jyoti Nangalia.
Shiny implementation - Jacob Grinfeld, with additional work by Eugene Nadezhdin.
Last update: August 2020.