Production and Curation of Parasite Reference Genomes

Production and Curation of Parasite Reference Genomes

Production and Curation of Parasite Reference Genomes

Overview

The Parasite Genomics Group is working on the assembly, annotation and manual curation of several different reference genomes. This includes the malaria parasite Plasmodium,  the Kinetoplastids Trypanosoma and Leishmania and the helminth Schistosoma mansoni.

Several Plasmodium genomes are manually curated and regularly updated with new assemblies. This includes the human malaria parasite P. falciparum 3D7, the chimpanzee parasite P. reichenowi, the rodent parasites P. berghei, P. chabaudi and P. yoelii, the human malaria parasite P. vivax and the simian and human parasite P. knowlesi. Manual curation involves the correction of gene structures based on transcriptome data and comparative genomics. Information is being extracted from scientific literature and integrated into the annotation. In additon to that valuable feedback is being given by the scientific community.

To explore up-to-date information about the reference genomes go to GeneDB.

At regular intervals data is being passed on to EupathDB to be integrated with additional functional genomics data, e.g. proteomics and transcriptomics data.

Manually curated Gene Ontology terms can be searched and downloaded using AmiGO.

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