Protein Interactions

Protein Interactions

Protein Interactions

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We employ affinity purification (epitope tagging) and tandem mass spectrometry to characterise protein complexes, and to map protein interaction networks and their dynamics.

Publications

  • Assignment of protein interactions from affinity purification/mass spectrometry data.

    Pardo M and Choudhary JS

    Journal of proteome research 2012;11;3;1462-74

  • Quantitative proteomics reveals the basis for the biochemical specificity of the cell-cycle machinery.

    Pagliuca FW, Collins MO, Lichawska A, Zegerman P, Choudhary JS and Pines J

    Molecular cell 2011;43;3;406-17

  • An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.

    Pardo M, Lang B, Yu L, Prosser H, Bradley A et al.

    Cell stem cell 2010;6;4;382-95

  • Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins.

    Fernández E, Collins MO, Uren RT, Kopanitsa MV, Komiyama NH et al.

    Molecular systems biology 2009;5;269