Post-Translational Modifications

Post-Translational Modifications

Post-Translational Modifications

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There are several levels at which we study protein modifications; the proteome level, the protein level and the modification level. We develop bioinformatics methods and analytical strategies for the identification of all detectable modifications. We also use enrichment techniques to target specific modifications, such as phosphorylation, for detailed analysis.

Publications

  • Analysis of protein palmitoylation reveals a pervasive role in Plasmodium development and pathogenesis.

    Jones ML, Collins MO, Goulding D, Choudhary JS and Rayner JC

    Cell host & microbe 2012;12;2;246-58

  • Neurotransmitters drive combinatorial multistate postsynaptic density networks.

    Coba MP, Pocklington AJ, Collins MO, Kopanitsa MV, Uren RT et al.

    Science signaling 2009;2;68;ra19

  • Phosphoproteomic analysis of the mouse brain cytosol reveals a predominance of protein phosphorylation in regions of intrinsic sequence disorder.

    Collins MO, Yu L, Campuzano I, Grant SG and Choudhary JS

    Molecular & cellular proteomics : MCP 2008;7;7;1331-48

  • Proteomic analysis of in vivo phosphorylated synaptic proteins.

    Collins MO, Yu L, Coba MP, Husi H, Campuzano I et al.

    The Journal of biological chemistry 2005;280;7;5972-82