Metabolomics Genetics

Metabolomics Genetics

Metabolomics Genetics

Genome-wide association scans with high-throughput metabolic profiling are powerful tools to study into how genetic variation influences metabolism and complex disease. We have carried out comprehensive explorations of genetic loci influencing human metabolism, comprising nearly 8 000 adult individuals of European ancestry. We have identified 145 metabolic loci connecting more than 400 different metabolites, defining the in vivo blueprint of human metabolism.

We have created a number of web-based tools and resources to facilitate access to the data, and including a Metabolomics Atlas to faciliate browsing the results of the study and a Metabolomics GWAS server to access genome-wide summary statistics.

External collaborators

Publications

  • Human metabolic individuality in biomedical and pharmaceutical research.

    Suhre K, Shin SY, Petersen AK, Mohney RP, Meredith D et al.

    Nature 2011;477;7362;54-60

  • An atlas of genetic influences on human blood metabolites.

    Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R et al.

    Nature genetics 2014;46;6;543-50

  • Interrogating causal pathways linking genetic variants, small molecule metabolites, and circulating lipids.

    Shin SY, Petersen AK, Wahl S, Zhai G, Römisch-Margl W et al.

    Genome medicine 2014;6;3;25

  • Biomarkers for type 2 diabetes and impaired fasting glucose using a nontargeted metabolomics approach.

    Menni C, Fauman E, Erte I, Perry JR, Kastenmüller G et al.

    Diabetes 2013;62;12;4270-6

  • Metabolomic identification of a novel pathway of blood pressure regulation involving hexadecanedioate.

    Menni C, Graham D, Kastenmüller G, Alharbi NH, Alsanosi SM et al.

    Hypertension (Dallas, Tex. : 1979) 2015;66;2;422-9

  • Long term conservation of human metabolic phenotypes and link to heritability.

    Yousri NA, Kastenmüller G, Gieger C, Shin SY, Erte I et al.

    Metabolomics : Official journal of the Metabolomic Society 2014;10;5;1005-1017