Cellular Generation and Phenotyping | Scientific Operations

Cellular Generation and Phenotyping | Scientific Operations

Cellular Generation and Phenotyping

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Our Research and Approach

The Cellular Generation and Phenotyping (CGaP) core facility provides central cell biology support to the Sanger Institute, in particular the scale-up and automation of existing faculty protocols to facilitate 'Science at Scale'.  The CGaP core facility takes a unique approach at the institute by partnering with faculty groups and acting as an extension of their existing team in order to deliver large scale projects.  The core has expertise in cell derivation from primary tissue, iPS derivation, cellular differentiation, phenotypic assays (eg high content imaging) and end point analysis (eg ELISA) and Luminex and functional bioassays

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People

Alderton, Alex
Dr Alex Alderton
Group Leader

Govan, Ceri

Govan, Ceri
Ceri Govan
Principal Technical Assistant

Key Projects, Collaborations, Tools & Data

The team are currently involved with a number of major projects at the Sanger Institute including HiPSCi ( www.hipsci.org) and INSIGNIA ( http://www.mutationsignatures.org/insignia/).  In addition, CGaP have grants independently of faculty programs with EBISC to produce iPS cells and with the MRC to work on next-generation stem cell culture systems.

Partners and Funders

CGaP currently have a number of external grants both independantly and as part of WTSI programs.  Staff on WSTI programs are funded via grants from the MRC and from core funded from the Wellcome Trust.  In addition CGaP have grants independatly of faculty programs with EBISC to produce iPS cells and with the MRC to work on next generation stem cell culture systems.
Internal Partners
External Partners and Funders

Publications

  • Successful Generation of Human Induced Pluripotent Stem Cell Lines from Blood Samples Held at Room Temperature for up to 48 hr.

    Agu CA, Soares FA, Alderton A, Patel M, Ansari R et al.

    Stem cell reports 2015;5;4;660-71