Cell Biology and in vivo models
The Sanger Institute's cell biology and in vivo models facilities and teams comprise:
Cellular Generation and Phenotyping
The Cellular Generation and Phenotyping (CGaP) core facility provides central cell biology support to the Sanger Institute, in particular the scale-up and automation of existing faculty protocols to facilitate 'Science at Scale'. The CGaP core facility takes a unique approach at the institute by partnering with faculty groups and acting as an extension of their existing team in order to deliver large scale projects. The core has expertise in cell derivation from primary tissue, iPS derivation, cellular differentiation, phenotypic assays (for example high content imaging) and end point analysis (such as ELISA) and Luminex and functional bioassays.
Model Pipelines are headed by Ramiro Ramirez-Solis and produce and characterise knock-out mice for large-scale research projects, including the Sanger Mouse Genetics Project KOMP2, EUCOMMTools, and the Infrafrontier projects.
Research Support Facility
Research Support Facility is headed by James Bussell and serves the Institute and worldwide community by providing and caring for the mice, zebrafish, rats and frogs used in research studies.
CGaP is a facility which works in partnership with faculty to enable large scale cell biology projects
We provide state-of-the-art molecular cytogenetics services to support the cutting-edge research of the institute, including gene mapping and karyotyping by fluorescence in situ hybridisation.
The cytometry core facility provides central flow cytometry analysis and cell sorting services to the Institute.
The Single Cell Genomics Core Facility provides high throughput single-cell isolation, amplification and library generation services.