GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
A3KP79_DANRE PPP1R12A ENSDARG00000076651 1 Not determined 1
ADAM12 ADAM12 ENSDARG00000079068 1 Not determined 3
angptl6 ANGPTL6 ENSDARG00000020265 None Not determined 2
arrb1 ARRB1 ENSDARG00000043241 2 Normal 1
asah2 ASAH2 ENSDARG00000012829 1 Not determined 2
bcat1 BCAT1 ENSDARG00000045568 None Not determined 2
BCKDHB (2 of 2) BCKDHB ENSDARG00000014676 1 Not determined 1
BCKDHB (1 of 2) BCKDHB ENSDARG00000086611 None Not determined 1
ca10a CA10 ENSDARG00000052644 1 Not determined 2
CD44 (1 of 2) CD44 ENSDARG00000089892 None Not determined 4
chrm3a CHRM3 ENSDARG00000071091 None Not determined 4
cox4i1 COX4I1 ENSDARG00000032970 None Not determined 1
cyp19a1a CYP19A1 ENSDARG00000041348 1 Not determined 6
cyp19a1b CYP19A1 ENSDARG00000009852 2 Not determined 6
dab2ip DAB2IP ENSDARG00000075110 3 Not determined 3
dvr1 GDF3 ENSDARG00000037995 1 Not determined 1
erlin1 ERLIN1 ENSDARG00000021991 None Not determined 2
fbxo8 FBXO8 ENSDARG00000007477 1 Not determined 1
gclm GCLM ENSDARG00000018953 None Not determined 1
golim4a GOLIM4 ENSDARG00000076498 None Not determined 2
golim4b GOLIM4 ENSDARG00000014545 1 Not determined 2
gpr126 GPR126 ENSDARG00000054137 3 1 phenotype 9
grin2aa GRIN2A ENSDARG00000034493 3 Not determined 3
grin2ab GRIN2A ENSDARG00000070543 2 Not determined 3
igf1 IGF1 ENSDARG00000094132 None Not determined 5
iqgap2 IQGAP2 ENSDARG00000060010 1 Not determined 2
jazf1a JAZF1 ENSDARG00000036243 1 Not determined 8
jazf1b JAZF1 ENSDARG00000056793 None Not determined 8
LOC100003272 STOX2 ENSDARG00000078572 None Not determined 1
LOC100007474 ANGPTL6 ENSDARG00000089667 None Not determined 2
LOC100007488 ANGPTL6 ENSDARG00000090557 None Not determined 2
LOC100148227 ANGPTL6 ENSDARG00000095746 None Not determined 2
LOC100149344 FBXO8 ENSDARG00000076702 None Not determined 1
LOC100149598 CHRM3 ENSDARG00000071298 None Not determined 4
LOC100151589 GRIN3A ENSDARG00000070511 1 Not determined 2
LOC100329239 FAM38B ENSDARG00000076005 1 Not determined 3
LOC560874 TNRC6C ENSDARG00000076847 3 Normal 1
LOC564832 GRIN3A ENSDARG00000075802 2 Not determined 2
LOC566107 TNRC6C ENSDARG00000076356 None Not determined 1
LOC566119 ANGPTL6 ENSDARG00000094845 1 Not determined 2
LOC568543 CA10 ENSDARG00000009568 4 Normal 2
LOC569960 NMUR1 ENSDARG00000003944 1 Not determined 1
LOC570630 EIF2C2 ENSDARG00000061268 3 Not determined 1
lox LOX ENSDARG00000003259 None Not determined 1
loxl5a LOX ENSDARG00000071680 None Not determined 1
loxl5b LOX ENSDARG00000076904 None Not determined 1
mef2ca MEF2C ENSDARG00000029764 1 Not determined 8
mef2cb MEF2C ENSDARG00000009418 1 Not determined 8
mfap4 ANGPTL6 ENSDARG00000090783 1 Not determined 2
myo10l2 MYO10 ENSDARG00000017004 4 Not determined 3
myo10l3 MYO10 ENSDARG00000074143 7 Not determined 3
NIPAL2 NIPAL2 ENSDARG00000087903 None Not determined 1
NP_001039321.2 LOX ENSDARG00000071676 None Not determined 1
olig3 OLIG3 ENSDARG00000074253 None Not determined 5
olig4 OLIG3 ENSDARG00000052610 1 Normal 5
pcdh15a PCDH15 ENSDARG00000052232 8 Normal 3
pcdh15b PCDH15 ENSDARG00000008127 4 Not determined 3
phf17 PHF17 ENSDARG00000033707 3 Not determined 1
PHLDB1 (1 of 2) PHLDB1 ENSDARG00000079378 1 Not determined 4
ppargc1al PPARGC1A ENSDARG00000067829 3 Not determined 1
ppp1r12a PPP1R12A ENSDARG00000010784 4 Not determined 1
si:ch211-119o8.6 ZNF626 ENSDARG00000026972 1 Not determined 1
si:ch211-213b8.4 PCDH15 ENSDARG00000095360 None Not determined 3
si:ch211-214o10.2 MFSD9 ENSDARG00000074728 None Not determined 2
si:ch211-221n23.1 ZNF238 ENSDARG00000028228 None Not determined 2
si:ch211-251b21.1 GRIN3A ENSDARG00000007275 None Not determined 2
si:ch211-276k2.5 NMUR1 ENSDARG00000060884 3 Not determined 1
si:ch211-39l18.4 CYP7B1 ENSDARG00000008858 1 Normal 3
si:dkey-10p5.9 TNRC6C ENSDARG00000078036 None Not determined 1
si:dkey-11f4.7 FAM38B ENSDARG00000074800 4 Not determined 3
si:dkey-11p10.6 ZDHHC20 ENSDARG00000058178 2 Not determined 1
si:dkey-252h13.1 PHLDB1 ENSDARG00000061093 1 Not determined 4
si:dkey-83f4.1 DAB2IP ENSDARG00000069484 2 Not determined 3
slc35f1 SLC35F1 ENSDARG00000053003 None Not determined 6
SLC39A11 SLC39A11 ENSDARG00000089127 None Not determined 4
stox2 STOX2 ENSDARG00000070162 1 Not determined 1
wdr37 WDR37 ENSDARG00000074611 None Not determined 2
wu:fa99e04 CD44 ENSDARG00000087863 1 Not determined 4
wu:fj11g02 ANGPTL6 ENSDARG00000038681 None Not determined 2
zgc:112020 NUDT12 ENSDARG00000043016 None Not determined 2
zgc:153912 MGAT1 ENSDARG00000036065 None Not determined 3
zgc:162723 ZDHHC20 ENSDARG00000055066 1 Not determined 1
zgc:171687 ANGPTL6 ENSDARG00000038682 None Not determined 2
zgc:173915 ANGPTL6 ENSDARG00000088745 1 Not determined 2
zgc:194119 HTR2B ENSDARG00000070940 2 Normal 1
zgc:66030 MGAT1 ENSDARG00000012407 2 Not determined 3
zgc:92279 EYA2 ENSDARG00000018984 2 Not determined 2

The following reported genes could not be linked automatically to a zebrafish gene:

  • AGBL1
  • c14ORF143
  • CDC14C
  • CT62
  • IDDM8
  • KLRA1
  • NELL-1
  • PMFBMP1
  • SCL9A2
  • UBL5
* quick link - http://q.sanger.ac.uk/blh051lg