GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
ARID5B ARID5B ENSDARG00000037196 None Not determined 7
atg5 ATG5 ENSDARG00000023396 1 Not determined 2
bach2 BACH2 ENSDARG00000004074 4 Not determined 14
bltk BLK ENSDARG00000007783 2 Not determined 11
CD44 (1 of 2) CD44 ENSDARG00000089892 None Not determined 4
cdkn1b CDKN1B ENSDARG00000054271 None Not determined 1
cdkn1bl CDKN1B ENSDARG00000029018 None Not determined 1
crebl2 CREBL2 ENSDARG00000094623 None Not determined 1
dda1 DDA1 ENSDARG00000076074 None Not determined 1
dguok DGUOK ENSDARG00000051983 None Not determined 2
dguok DGUOK ENSDARG00000075395 None Not determined 2
dram1 DRAM1 ENSDARG00000045561 1 Not determined 1
gpr19 GPR19 ENSDARG00000041125 None Not determined 1
ikzf1 IKZF1 ENSDARG00000013539 3 Not determined 10
irf5 IRF5 ENSDARG00000045681 None Not determined 14
ITGAM ITGAM ENSDARG00000002956 4 Not determined 5
LOC557210 BACH2 ENSDARG00000036569 3 Not determined 14
mhc2dab HLA-DRB1 ENSDARG00000079105 None Not determined 35
NP_001038387.1 SCN10A ENSDARG00000059692 5 Not determined 8
NP_001091732.1 HLA-DRB1 ENSDARG00000071168 1 Not determined 35
NP_997957.1 CDKN1B ENSDARG00000088081 None Not determined 1
prdm1a PRDM1 ENSDARG00000002445 3 Not determined 3
prdm1b PRDM1 ENSDARG00000053592 4 Not determined 3
prdm1c PRDM1 ENSDARG00000078161 None Not determined 3
rasgrp3 RASGRP3 ENSDARG00000077864 None Not determined 3
rtkn2 RTKN2 ENSDARG00000053558 None Not determined 3
si:busm1-104n07.3 HLA-DRB1 ENSDARG00000074510 1 Normal 35
si:busm1-160c18.3 HLA-DRB1 ENSDARG00000053738 None Not determined 35
si:busm1-160c18.3 HLA-DRB1 ENSDARG00000093706 None Not determined 35
si:busm1-194e12.12 HLA-DRB1 ENSDARG00000055447 None Not determined 35
si:busm1-228j01.4 HLA-DRB1 ENSDARG00000088872 1 Not determined 35
si:busm1-228j01.6 HLA-DRB1 ENSDARG00000041705 None Not determined 35
si:ch211-220a11.1 TET3 ENSDARG00000062646 2 Not determined 2
si:ch211-274c22.6 TNFAIP3 ENSDARG00000027777 4 Not determined 11
si:ch73-90n13.2 UHRF1BP1 ENSDARG00000077011 None Not determined 2
si:dkey-282h22.6 SEZ6L2 ENSDARG00000076052 6 Not determined 2
si:dkey-37h18.2 SLC29A3 ENSDARG00000077828 None Not determined 3
si:dkey-70o15.2 WDFY4 ENSDARG00000077009 6 Not determined 4
si:zfos-2070c2.3 HLA-DRB1 ENSDARG00000076307 None Not determined 35
stat4 STAT4 ENSDARG00000028731 2 Not determined 19
tnip1 TNIP1 ENSDARG00000015653 2 Not determined 6
ube2l3a UBE2L3 ENSDARG00000019188 None Not determined 8
ube2l3b UBE2L3 ENSDARG00000027141 None Not determined 8
wu:fa99e04 CD44 ENSDARG00000087863 1 Not determined 4
wu:fd58b11 HLA-DRB1 ENSDARG00000054921 None Not determined 35
zgc:153067 HLA-DRB1 ENSDARG00000056330 1 Not determined 35
zgc:158706 ARID5B ENSDARG00000069988 None Not determined 7
zgc:56230 CLEC16A ENSDARG00000038094 2 Not determined 13
zgc:63767 SLC15A4 ENSDARG00000000384 2 Not determined 2
zgc:77151 ARID5B ENSDARG00000054307 1 Not determined 7

The following reported genes could not be linked automatically to a zebrafish gene:

  • APOBEC4
  • BANK1
  • CD80
  • ELF1
  • ETS1
  • TNFSF4
* quick link - http://q.sanger.ac.uk/q2pgxi2m