GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
a1cf A1CF ENSDARG00000002968 None Not determined 1
A7MC17_DANRE SLC22A7 ENSDARG00000062182 2 Not determined 1
abcg2a ABCG2 ENSDARG00000043037 None Not determined 10
abcg2b ABCG2 ENSDARG00000079361 None Not determined 10
abcg2c ABCG2 ENSDARG00000058574 3 Not determined 10
abcg2d ABCG2 ENSDARG00000016818 1 Not determined 10
acvr1b ACVR1B ENSDARG00000018968 3 Normal 1
acvr2a ACVR2A ENSDARG00000011188 None Not determined 2
ACVR2A (2 of 2) ACVR2A ENSDARG00000079944 2 Not determined 2
acvrl1 ACVRL1 ENSDARG00000018179 None Not determined 1
adpgk ADPGK ENSDARG00000063525 1 Not determined 1
adpgk2 ADPGK ENSDARG00000062785 None Not determined 1
ankrd55 ANKRD55 ENSDARG00000053869 4 Not determined 6
arnt ARNT ENSDARG00000021855 1 Not determined 2
asah2 ASAH2 ENSDARG00000012829 1 Not determined 2
b4galt1 B4GALT1 ENSDARG00000002634 None Not determined 2
baz1b BAZ1B ENSDARG00000061394 2 Not determined 3
bcas3 BCAS3 ENSDARG00000054893 2 Normal 8
bcas3 BCAS3 ENSDARG00000090764 None Not determined 8
bmpr2a BMPR2 ENSDARG00000011941 None Not determined 1
bmpr2b BMPR2 ENSDARG00000020057 2 Not determined 1
dab2 DAB2 ENSDARG00000031761 None Not determined 3
dachc DACH1 ENSDARG00000003142 1 Not determined 5
fgf5 FGF5 ENSDARG00000035377 None Not determined 4
FRK FRK ENSDARG00000027807 None Not determined 3
HDAC7 (1 of 2) HDAC7 ENSDARG00000093701 None Not determined 2
hnf1a HNF1A ENSDARG00000009470 None Not determined 21
hnf4g HNF4G ENSDARG00000071565 1 Not determined 2
igf1ra IGF1R ENSDARG00000027423 1 Not determined 3
igf1rb IGF1R ENSDARG00000034434 5 Not determined 3
inhbb INHBB ENSDARG00000040777 1 Not determined 4
INHBE INHBC ENSDARG00000040780 None Not determined 2
INHBE INHBE ENSDARG00000040780 None Not determined 1
insra INSR ENSDARG00000011948 2 Normal 6
insrb INSR ENSDARG00000071524 2 Not determined 6
LOC100000058 SLC22A7 ENSDARG00000056652 1 Not determined 1
LOC100001249 SLC22A7 ENSDARG00000054690 None Not determined 1
LOC100001249 SLC22A11 ENSDARG00000054690 None Not determined 4
LOC100001249 SLC22A12 ENSDARG00000054690 None Not determined 4
LOC100001838 SLC22A7 ENSDARG00000091252 None Not determined 1
LOC100002673 USP2 ENSDARG00000087495 None Not determined 1
LOC100332699 HDAC7 ENSDARG00000089416 1 Not determined 2
LOC100332907 BAZ1B ENSDARG00000053572 1 Not determined 3
LOC100333044 GCKR ENSDARG00000086620 None Not determined 39
LOC559222 ACVR1B ENSDARG00000052142 None Not determined 1
LOC559807 MUSTN1 ENSDARG00000054026 None Not determined 2
LOC564054 USP2 ENSDARG00000074120 None Not determined 1
LOC569905 TRIM46 ENSDARG00000012367 4 Not determined 1
LOC792596 HDAC7 ENSDARG00000073850 None Not determined 2
ltbp3 LTBP3 ENSDARG00000035682 2 Not determined 2
maf MAF ENSDARG00000015890 1 Not determined 8
MAF (1 of 2) MAF ENSDARG00000076520 1 Not determined 8
mc4r MC4R ENSDARG00000015515 3 2 normal 14
mid2 TRIM46 ENSDARG00000034871 2 Normal 1
nfat5 NFAT5 ENSDARG00000020872 3 Normal 2
NFAT5 (1 of 2) NFAT5 ENSDARG00000014022 2 Not determined 2
NP_001107902.1 SLC2A9 ENSDARG00000063288 3 1 phenotype 14
NP_001183982.1 MUSTN1 ENSDARG00000089086 None Not determined 2
NP_001183988.1 HLF ENSDARG00000061011 2 Not determined 1
NRXN2 (4 of 4) NRXN2 ENSDARG00000076051 None Not determined 2
NRXN2 (1 of 4) NRXN2 ENSDARG00000063606 None Not determined 2
nrxn2a NRXN2 ENSDARG00000061454 3 Not determined 2
nrxn2b NRXN2 ENSDARG00000063150 1 Not determined 2
ovol1 OVOL1 ENSDARG00000076472 None Not determined 4
pdzk1 PDZK1 ENSDARG00000022261 None Not determined 3
PKLR PKLR ENSDARG00000042010 1 Not determined 2
prkag2 PRKAG2 ENSDARG00000001933 1 Not determined 5
PRPSAP1 PRPSAP1 ENSDARG00000036524 None Not determined 1
ptpn11a PTPN11 ENSDARG00000020334 1 Not determined 8
SFMBT1 SFMBT1 ENSDARG00000044915 1 Not determined 2
si:ch1073-189o9.1 MLXIPL ENSDARG00000089107 None Not determined 13
si:ch211-266d19.3 RREB1 ENSDARG00000063701 1 Not determined 6
si:ch211-279l9.6 RREB1 ENSDARG00000042652 3 Not determined 6
si:ch73-105b23.1 LTBP3 ENSDARG00000087558 4 Normal 2
si:dkey-119m7.4 SLC22A7 ENSDARG00000071049 4 Normal 1
si:dkey-119m7.4 SLC22A11 ENSDARG00000071049 4 Normal 4
si:dkey-119m7.4 SLC22A12 ENSDARG00000071049 4 Normal 4
si:dkey-165i4.1 ATXN2 ENSDARG00000052897 4 Normal 10
si:dkey-17e16.13 OVOL1 ENSDARG00000078256 1 Not determined 4
si:dkey-30j22.1 LTBP3 ENSDARG00000042829 2 Not determined 2
si:dkeyp-39e9.3 TRIM46 ENSDARG00000058649 1 Not determined 1
slc16a9a SLC16A9 ENSDARG00000013926 1 Not determined 3
slc16a9b SLC16A9 ENSDARG00000005947 2 Not determined 3
slc22a7a SLC22A7 ENSDARG00000056028 None Not determined 1
slc22a7b SLC22A7 ENSDARG00000056643 1 1 phenotype 1
slc2a11b SLC2A9 ENSDARG00000093395 2 1 phenotype 14
slc2a15a SLC2A9 ENSDARG00000029894 None Not determined 14
slc2a15b SLC2A9 ENSDARG00000053269 1 Not determined 14
stc1 STC1 ENSDARG00000003303 1 Not determined 3
stc1l STC1 ENSDARG00000058476 None Not determined 3
ube2q1 UBE2Q2 ENSDARG00000007714 1 Not determined 2
ube2q2 UBE2Q2 ENSDARG00000013990 1 Not determined 2
usp2a USP2 ENSDARG00000020107 2 Not determined 1
vegfaa VEGFA ENSDARG00000045971 None Not determined 8
vegfab VEGFA ENSDARG00000034700 1 Not determined 8
zgc:153035 HLF ENSDARG00000074752 None Not determined 1
zgc:153329 PRKAG2 ENSDARG00000012625 None Not determined 5
zgc:154116 B4GALT1 ENSDARG00000052326 2 Not determined 2
zgc:158869 DACH1 ENSDARG00000069440 3 Not determined 5

The following reported genes could not be linked automatically to a zebrafish gene:

  • B3GNT4
  • C17orf82
  • NRG4
  • ORC4L
  • QRICH2
  • SLC17A1
  • SLC17A3
  • TMEM171
* quick link - http://q.sanger.ac.uk/13r6k77a