GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
A5WV62_DANRE STK36 ENSDARG00000075091 None Not determined 1
anks1b ANKS1B ENSDARG00000003512 5 Not determined 7
ARAP2 ARAP2 ENSDARG00000056389 6 Not determined 1
arhgef1 ARHGEF2 ENSDARG00000040380 3 Not determined 1
cenpv CENPV ENSDARG00000092285 None Not determined 1
cpne4 CPNE4 ENSDARG00000062754 2 Not determined 2
ifrd1 IFRD1 ENSDARG00000068708 None Not determined 2
LOC556494 STK36 ENSDARG00000079925 1 Not determined 1
nrxn3a NRXN3 ENSDARG00000043746 7 Not determined 5
nrxn3b NRXN3 ENSDARG00000062693 6 Not determined 5
pcsk5a PCSK5 ENSDARG00000067537 5 Normal 5
pcsk5b PCSK5 ENSDARG00000060518 None Not determined 5
pigl PIGL ENSDARG00000067752 None Not determined 1
ptprfa PTPRF ENSDARG00000076810 6 Not determined 1
ptprfb PTPRF ENSDARG00000005754 4 Not determined 1
si:ch211-147h1.4 STK36 ENSDARG00000045157 6 Not determined 1
si:ch211-165a10.2 STK36 ENSDARG00000091960 None Not determined 1
si:ch211-165a10.4 STK36 ENSDARG00000094014 None Not determined 1
si:ch211-165a10.5 STK36 ENSDARG00000093718 1 Not determined 1
si:ch211-241e1.3 LAMA3 ENSDARG00000022615 4 Not determined 1
si:ch211-255l14.1 STK36 ENSDARG00000093094 None Not determined 1
si:ch211-255l14.3 STK36 ENSDARG00000051894 None Not determined 1
si:ch211-255l14.5 STK36 ENSDARG00000095541 None Not determined 1
si:ch211-281k19.2 STK36 ENSDARG00000094381 None Not determined 1
si:ch211-67e16.9 TTLL4 ENSDARG00000078935 1 Not determined 1
si:dkey-110c1.7 UNC13A ENSDARG00000061829 3 Not determined 3
si:dkey-11p23.1 CPNE4 ENSDARG00000040069 None Not determined 2
si:dkey-121a11.10 LAMA3 ENSDARG00000071462 6 Not determined 1
si:dkey-22i16.10 STK36 ENSDARG00000078558 None Not determined 1
si:dkey-80c24.1 STK36 ENSDARG00000070692 None Not determined 1
si:dkey-80c24.5 STK36 ENSDARG00000092501 1 Not determined 1
si:dkey-91i10.2 ARHGEF2 ENSDARG00000074034 1 Not determined 1
si:dkeyp-67e1.2 STK36 ENSDARG00000092720 None Not determined 1
si:dkeyp-67e1.4 STK36 ENSDARG00000092374 None Not determined 1
si:dkeyp-67e1.6 STK36 ENSDARG00000073947 None Not determined 1
si:dkeyp-93h6.1 STK36 ENSDARG00000092928 None Not determined 1
st3gal3 ST3GAL3 ENSDARG00000015374 3 Not determined 2
st3gal3l ST3GAL3 ENSDARG00000015252 None Not determined 2
stk36 STK36 ENSDARG00000061095 2 Not determined 1
UNC13A (5 of 5) UNC13A ENSDARG00000091647 None Not determined 3
UNC13A (3 of 5) UNC13A ENSDARG00000090528 None Not determined 3
UNC13A (2 of 5) UNC13A ENSDARG00000091504 None Not determined 3
UNC13A (1 of 5) UNC13A ENSDARG00000087214 None Not determined 3
wu:fj11d04 ARHGEF2 ENSDARG00000075819 2 Not determined 1
zgc:100846 C9orf72 ENSDARG00000011837 None Not determined 3
zgc:162316 CNOT2 ENSDARG00000061802 1 Not determined 1
zgc:91860 KIAA0513 ENSDARG00000041599 None Not determined 1
znf142 ZNF142 ENSDARG00000061373 3 Not determined 1

The following reported genes could not be linked automatically to a zebrafish gene:

  • JMJD2A
* quick link - http://q.sanger.ac.uk/0oek7qgs