GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
ACSL6 ACSL6 ENSDARG00000060317 None Not determined 2
adoa ADO ENSDARG00000042827 1 Not determined 4
adob ADO ENSDARG00000053571 None Not determined 4
ak3 AK3 ENSDARG00000058226 2 Normal 3
atg16l1 ATG16L1 ENSDARG00000057430 None Not determined 8
BTNL9 MOG ENSDARG00000067794 None Not determined 2
cox15 COX15 ENSDARG00000075933 1 Not determined 2
cutc CUTC ENSDARG00000077306 1 Not determined 2
cylda CYLD ENSDARG00000060058 4 Not determined 3
EHBP1 EHBP1 ENSDARG00000043643 2 Not determined 3
gabbr1a GABBR1 ENSDARG00000018967 3 Not determined 2
gabbr1b GABBR1 ENSDARG00000016667 1 Not determined 2
got1 GOT1 ENSDARG00000039093 1 Not determined 2
il12rb2 IL12RB2 ENSDARG00000052157 None Not determined 7
IL12RB2 (1 of 2) IL12RB2 ENSDARG00000093809 None Not determined 7
il12rb2l IL12RB2 ENSDARG00000074850 None Not determined 7
il23r IL12RB2 ENSDARG00000052158 1 Not determined 7
kcnb2 KCNB2 ENSDARG00000038862 1 Not determined 4
ldb3b PDLIM4 ENSDARG00000019202 None Not determined 2
LOC100000685 SLC22A4 ENSDARG00000068603 2 Not determined 5
LOC100332846 ACSL6 ENSDARG00000078399 3 Not determined 2
LOC100333117 CYLD ENSDARG00000068386 None Not determined 3
LOC555864 RDH10 ENSDARG00000028862 1 Not determined 1
LOC793832 KIAA1841 ENSDARG00000079857 4 Not determined 2
LOC794759 SNX20 ENSDARG00000045554 1 Not determined 1
LOC799320 ZNF365 ENSDARG00000087985 None Not determined 11
MFRN2_DANRE SLC25A28 ENSDARG00000052994 None Not determined 2
nkd1 NKD1 ENSDARG00000020053 2 Not determined 1
nkx2.3 NKX2-3 ENSDARG00000039095 1 Not determined 10
nkx2.7 NKX2-3 ENSDARG00000021232 1 1 phenotype 10
nod2 NOD2 ENSDARG00000010756 3 Not determined 10
NP_999879.1 SERBP1 ENSDARG00000074580 None Not determined 1
p4ha2 P4HA2 ENSDARG00000010085 1 Not determined 1
papolg PAPOLG ENSDARG00000012141 3 Not determined 1
pdlim4 PDLIM4 ENSDARG00000068973 1 Not determined 2
pex13 PEX13 ENSDARG00000071037 2 Not determined 1
psmb10 PSMB10 ENSDARG00000001656 None Not determined 1
ptger4a PTGER4 ENSDARG00000059236 1 Normal 12
ptger4b PTGER4 ENSDARG00000035415 1 Not determined 12
rdh10a RDH10 ENSDARG00000058730 1 Not determined 1
rdh10b RDH10 ENSDARG00000012369 None Not determined 1
rel REL ENSDARG00000055276 5 Not determined 10
rpl7 RPL7 ENSDARG00000007320 None Not determined 1
sag SAG ENSDARG00000038378 1 Not determined 2
serbp1 SERBP1 ENSDARG00000074242 None Not determined 1
si:ch1073-409b12.4 SLC22A4 ENSDARG00000094112 None Not determined 5
si:ch211-234e14.2 PTGER4 ENSDARG00000079907 None Not determined 12
si:ch211-87h14.4 CPAMD8 ENSDARG00000092844 None Not determined 2
si:ch73-194h10.1 INPP5D ENSDARG00000074283 1 Not determined 2
si:ch73-233m11.2 NOD2 ENSDARG00000091859 None Not determined 10
si:ch73-68b22.2 P4HA2 ENSDARG00000094609 None Not determined 1
si:dkey-178e17.3 C8orf84 ENSDARG00000058658 None Not determined 1
si:dkey-192j17.1 KCNB2 ENSDARG00000088842 1 Not determined 4
si:dkey-217m5.3 CCL2 ENSDARG00000041919 None Not determined 4
si:dkey-217m5.3 CCL8 ENSDARG00000041919 None Not determined 1
si:dkey-217m5.3 CCL7 ENSDARG00000041919 None Not determined 2
si:dkey-217m5.3 CCL11 ENSDARG00000041919 None Not determined 2
si:dkey-217m5.3 CCL13 ENSDARG00000041919 None Not determined 2
si:dkey-94n12.1 CPAMD8 ENSDARG00000056530 None Not determined 2
si:dkeyp-22h2.1 CNNM1 ENSDARG00000078087 1 Not determined 1
si:dkeyp-59a8.1 CCL7 ENSDARG00000041923 None Not determined 2
si:dkeyp-59a8.1 CCL11 ENSDARG00000041923 None Not determined 2
si:dkeyp-59a8.1 CCL13 ENSDARG00000041923 None Not determined 2
si:dkeyp-59a8.1 CCL2 ENSDARG00000041923 None Not determined 4
si:dkeyp-59a8.1 CCL8 ENSDARG00000041923 None Not determined 1
si:dkeyp-59a8.2 CCL7 ENSDARG00000041835 None Not determined 2
si:dkeyp-59a8.2 CCL11 ENSDARG00000041835 None Not determined 2
si:dkeyp-59a8.2 CCL13 ENSDARG00000041835 None Not determined 2
si:dkeyp-59a8.2 CCL2 ENSDARG00000041835 None Not determined 4
si:dkeyp-59a8.2 CCL8 ENSDARG00000041835 None Not determined 1
si:dkeyp-59a8.3 CCL7 ENSDARG00000041917 None Not determined 2
si:dkeyp-59a8.3 CCL11 ENSDARG00000041917 None Not determined 2
si:dkeyp-59a8.3 CCL13 ENSDARG00000041917 None Not determined 2
si:dkeyp-59a8.3 CCL2 ENSDARG00000041917 None Not determined 4
si:dkeyp-59a8.3 CCL8 ENSDARG00000041917 None Not determined 1
slc22a4 SLC22A4 ENSDARG00000005335 2 Not determined 5
slc25a28 SLC25A28 ENSDARG00000074297 None Not determined 2
slc35d1a SLC35D1 ENSDARG00000011973 1 Not determined 1
slc35d1b SLC35D1 ENSDARG00000027986 1 Not determined 1
SLC43A3 (1 of 2) SLC43A3 ENSDARG00000059682 None Not determined 1
TCERG1L TCERG1L ENSDARG00000087127 None Not determined 4
terf1 TERF1 ENSDARG00000058710 1 Not determined 1
ubc UBD ENSDARG00000067755 None Not determined 1
usp34 USP34 ENSDARG00000037734 2 Not determined 1
usp40 USP40 ENSDARG00000071197 3 Not determined 2
wu:fc66f06 SERBP1 ENSDARG00000087421 1 Not determined 1
zgc:112294 TMEM17 ENSDARG00000010602 None Not determined 1
zgc:136890 SLC43A3 ENSDARG00000057949 2 Not determined 1
zgc:152670 P4HA2 ENSDARG00000017038 None Not determined 1
zgc:163141 TMEM17 ENSDARG00000074518 None Not determined 1
zgc:171472 PUS10 ENSDARG00000079973 None Not determined 4
zgc:66109 SAG ENSDARG00000012610 4 Not determined 2
zgc:92791 PSMB10 ENSDARG00000043781 1 Not determined 1

The following reported genes could not be linked automatically to a zebrafish gene:

  • C1orf141
  • C2orf74
  • CCL1
  • DGKD
  • ENTPD7
  • ERG2
  • HLA-A
  • HLA-F
  • HLA-G
  • HLA-H
  • IL23R
  • IL3
  • PRG2
  • PRG3
  • SLCO6A1
* quick link - http://q.sanger.ac.uk/agesrk2d