GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
A6H8T0_DANRE SYCP2L ENSDARG00000079190 None Not determined 3
ash2l ASH2L ENSDARG00000060392 4 Not determined 1
helq HELQ ENSDARG00000079818 2 Not determined 1
kpna3 KPNA3 ENSDARG00000052641 2 Not determined 2
LOC100332160 UIMC1 ENSDARG00000091187 None Not determined 3
LOC100332162 FNDC4 ENSDARG00000009949 None Not determined 4
LOC100333576 MCM8 ENSDARG00000074326 2 Not determined 4
LOC560613 POLG ENSDARG00000060951 1 Not determined 2
prim1 PRIM1 ENSDARG00000040163 None Not determined 1
rhbdl2 RHBDL2 ENSDARG00000069833 None Not determined 1
rnf44 RNF44 ENSDARG00000068582 1 Not determined 1
si:ch211-251j10.5 HELQ ENSDARG00000077536 4 Not determined 1
si:dkey-71h2.1 FNDC4 ENSDARG00000043396 None Not determined 4
tlk1a TLK1 ENSDARG00000042467 2 Not determined 1
tlk1b TLK1 ENSDARG00000059190 2 Not determined 1
UIMC1 (2 of 2) UIMC1 ENSDARG00000089679 None Not determined 3
zgc:123244 TMEM150B ENSDARG00000056144 None Not determined 1
zgc:55521 EXO1 ENSDARG00000056832 1 Not determined 1
zgc:77174 TDRD3 ENSDARG00000025421 1 Not determined 2

The following reported genes could not be linked automatically to a zebrafish gene:

  • NLRP11
  • PRRC2A
* quick link - http://q.sanger.ac.uk/ub6m8wne