GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
ABCB11 ABCB11 ENSDARG00000070078 2 Not determined 6
abcb11a ABCB11 ENSDARG00000011573 4 Not determined 6
abhd12 ABHD12 ENSDARG00000071004 None Not determined 1
aldh5a1 ALDH5A1 ENSDARG00000076544 1 Not determined 1
aldob ALDOB ENSDARG00000053684 None Not determined 1
alp ALPL ENSDARG00000015546 None Not determined 6
B8JKB7_DANRE MYO1B ENSDARG00000092430 2 Not determined 2
ccbl2 CCBL2 ENSDARG00000013423 None Not determined 1
ccbl2 CCBL2 ENSDARG00000043280 None Not determined 1
CCBL2 (4 of 4) CCBL2 ENSDARG00000094766 None Not determined 1
cd276 CD276 ENSDARG00000003061 2 Normal 2
cdh10 CDH6 ENSDARG00000055843 2 Normal 2
cdh6 CDH6 ENSDARG00000014522 2 Not determined 2
cept1 CEPT1 ENSDARG00000021177 2 Not determined 1
cpn1 CPN1 ENSDARG00000005185 1 Not determined 4
ddt DDTL ENSDARG00000044751 None Not determined 1
ddt DDT ENSDARG00000044751 None Not determined 1
dennd2d DENND2D ENSDARG00000030250 None Not determined 1
dlg4 DLG4 ENSDARG00000039385 None Not determined 1
dlg4 DLG4 ENSDARG00000041926 1 Not determined 1
DLG4 (2 of 3) DLG4 ENSDARG00000077552 None Not determined 1
dlg5 DLG5 ENSDARG00000074059 7 Not determined 2
DLG5 (4 of 4) DLG5 ENSDARG00000075408 2 Not determined 2
DLG5 (3 of 4) DLG5 ENSDARG00000090949 None Not determined 2
DLG5 (2 of 4) DLG5 ENSDARG00000086014 None Not determined 2
dpm3 DPM3 ENSDARG00000058650 1 Not determined 1
efna1a EFNA1 ENSDARG00000030326 None Not determined 2
efna1b EFNA1 ENSDARG00000018787 None Not determined 2
epha2 EPHA2 ENSDARG00000017354 4 2 normal 1
EPHA2 (1 of 2) EPHA2 ENSDARG00000022727 8 Not determined 1
fads2 FADS2 ENSDARG00000019532 None Not determined 15
ggt1 GGTLC2 ENSDARG00000023526 None Not determined 1
ggt1 GGT1 ENSDARG00000023526 None Not determined 4
gins1 GINS1 ENSDARG00000007624 None Not determined 1
gstt1a GSTT2B ENSDARG00000042428 None Not determined 1
gstt1a GSTT1 ENSDARG00000042428 None Not determined 1
gstt1b GSTT2B ENSDARG00000017388 2 Not determined 1
gstt1b GSTT1 ENSDARG00000017388 2 Not determined 1
hnf1a HNF1A ENSDARG00000009470 None Not determined 21
jmjd1c JMJD1C ENSDARG00000079939 6 Not determined 11
LOC100001191 DYNLRB2 ENSDARG00000089952 None Not determined 2
LOC100333044 GCKR ENSDARG00000086620 None Not determined 39
LOC100334818 SLC2A2 ENSDARG00000001937 None Not determined 3
LOC569014 GGT1 ENSDARG00000018342 1 Not determined 4
LOC569014 GGTLC2 ENSDARG00000018342 1 Not determined 1
LOC571201 CCBL2 ENSDARG00000093893 1 Not determined 1
LOC571581 NRBF2 ENSDARG00000044096 1 Not determined 1
LOC571586 JMJD1C ENSDARG00000077805 5 Not determined 11
LOC794105 GGTLC2 ENSDARG00000087063 None Not determined 1
LOC794105 GGT1 ENSDARG00000087063 None Not determined 4
LOC797620 CD276 ENSDARG00000074235 1 Not determined 2
mapk10 MAPK10 ENSDARG00000025747 1 Not determined 1
mical3 MICAL3 ENSDARG00000021979 3 Not determined 2
mif MIF ENSDARG00000071336 None Not determined 1
myo1bl2 MYO1B ENSDARG00000024694 2 Not determined 2
nedd4l NEDD4L ENSDARG00000060006 1 Not determined 3
nrbf2 NRBF2 ENSDARG00000023591 None Not determined 1
PKLR PKLR ENSDARG00000042010 1 Not determined 2
pkn2 PKN2 ENSDARG00000006705 1 Not determined 3
pkn3 PKN2 ENSDARG00000079585 1 Not determined 3
PMFBP1 PMFBP1 ENSDARG00000087389 1 Not determined 1
ppp1r3b PPP1R3B ENSDARG00000044691 None Not determined 9
pygb PYGB ENSDARG00000002021 1 Not determined 1
roraa RORA ENSDARG00000031768 1 Not determined 11
rorab RORA ENSDARG00000001910 1 Not determined 11
samm50 SAMM50 ENSDARG00000045814 2 Not determined 4
samm50l SAMM50 ENSDARG00000039681 None Not determined 4
si:ch1073-189o9.1 MLXIPL ENSDARG00000089107 None Not determined 13
si:ch211-167h3.2 ATP8B1 ENSDARG00000094582 1 Not determined 3
si:ch211-180b7.2 ATP8B1 ENSDARG00000060980 5 Not determined 3
si:ch211-215c3.2 ZNF827 ENSDARG00000076171 6 Not determined 4
si:ch211-281l24.1 EFHD1 ENSDARG00000043446 None Not determined 1
si:ch211-67f13.8 CD276 ENSDARG00000079155 2 Not determined 2
si:ch73-137d22.1 CD276 ENSDARG00000039257 None Not determined 2
si:dkey-208b23.1 CEPT1 ENSDARG00000058716 1 Not determined 1
si:dkey-222h21.12 GGTLC2 ENSDARG00000092350 None Not determined 1
si:dkey-222h21.12 GGT1 ENSDARG00000092350 None Not determined 4
si:dkey-222h21.13 GGTLC2 ENSDARG00000087054 1 Not determined 1
si:dkey-222h21.13 GGT1 ENSDARG00000087054 1 Not determined 4
si:dkey-222h21.14 GGT1 ENSDARG00000075055 None Not determined 4
si:dkey-222h21.14 GGTLC2 ENSDARG00000075055 None Not determined 1
si:dkey-242g16.2 PPP1R3B ENSDARG00000069377 None Not determined 9
si:dkey-26c10.6 EPHA2 ENSDARG00000057729 None Not determined 1
si:dkey-27b3.5 ITGA1 ENSDARG00000074316 2 Not determined 5
si:dkey-45k15.2 C14orf73 ENSDARG00000058180 4 Not determined 3
si:dkey-71p21.13 CD276 ENSDARG00000076139 1 Not determined 2
si:dkeyp-27e10.1 MICAL3 ENSDARG00000094732 1 Not determined 2
slc2a2 SLC2A2 ENSDARG00000056196 None Not determined 3
st3gal4 ST3GAL4 ENSDARG00000041006 3 Not determined 2
stat4 STAT4 ENSDARG00000028731 2 Not determined 19
trib1 TRIB1 ENSDARG00000076142 1 Not determined 12
zgc:123297 CD276 ENSDARG00000056798 1 Not determined 2
zgc:153628 DENND2D ENSDARG00000058666 None Not determined 1
zgc:153911 CD276 ENSDARG00000002509 1 Not determined 2
zgc:153916 PKN2 ENSDARG00000036707 2 Not determined 3
zgc:153943 C9orf125 ENSDARG00000061553 1 Not determined 1
zgc:162154 CD276 ENSDARG00000079170 None Not determined 2
zgc:172120 CD276 ENSDARG00000069199 1 Not determined 2
zgc:66350 GSTT2B ENSDARG00000095464 None Not determined 1
zgc:66350 GSTT1 ENSDARG00000095464 None Not determined 1
zgc:73269 C11orf10 ENSDARG00000078785 None Not determined 4
zgc:77112 PPP1R3B ENSDARG00000015657 None Not determined 9
zgc:92195 PNPLA3 ENSDARG00000044086 1 Not determined 6

The following reported genes could not be linked automatically to a zebrafish gene:

  • ABO
  • ASGR1
  • C12orf27
  • C2orf16
  • FADS1
  • FLJ37644
  • FUT2
  • FUT2
  • GPLD1
  • HPR
  • HSD17B13
  • LOC100129166
  • MLIP
  • NBPF3
  • RSG1
  • SOX9
* quick link - http://q.sanger.ac.uk/ccon840m