GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
aebp2 AEBP2 ENSDARG00000006038 1 Not determined 2
armc2 ARMC2 ENSDARG00000022660 4 Not determined 2
asb1 ASB1 ENSDARG00000026635 None Not determined 1
c10orf11 C10orf11 ENSDARG00000057166 1 Not determined 3
cdc123 CDC123 ENSDARG00000075025 1 Not determined 5
chrna5 CHRNA5 ENSDARG00000003420 3 Normal 13
ddx1 DDX1 ENSDARG00000093213 2 Not determined 3
hdac4 HDAC4 ENSDARG00000041204 3 Not determined 4
LOC100332699 HDAC4 ENSDARG00000089416 1 Not determined 4
LOC559723 TGFB2 ENSDARG00000071879 2 Not determined 2
LOC568467 CHRNA3 ENSDARG00000054497 2 Not determined 15
mecom MECOM ENSDARG00000060808 2 Not determined 7
mfap2 MFAP2 ENSDARG00000059367 None Not determined 3
mhc1uba MICB ENSDARG00000075963 None Not determined 7
mhc1ze MICB ENSDARG00000074765 None Not determined 7
mhc1zel MICB ENSDARG00000092162 1 Not determined 7
mhc2dab HLA-DQB1 ENSDARG00000079105 None Not determined 24
MMP15 (2 of 2) MMP15 ENSDARG00000051962 1 Not determined 2
MMP15 (1 of 2) MMP15 ENSDARG00000013072 2 Not determined 2
NP_001025134.1 PPP1R14C ENSDARG00000077341 None Not determined 1
NP_001091732.1 HLA-DQB1 ENSDARG00000071168 1 Not determined 24
NP_001184253.1 DDX1 ENSDARG00000032117 2 Not determined 3
NP_919406.1 MICB ENSDARG00000086877 1 Not determined 7
Q8MHB3_DANRE MICB ENSDARG00000076734 None Not determined 7
Q8MHB6_DANRE MICB ENSDARG00000088022 1 Not determined 7
si:busm1-104n07.3 HLA-DQB1 ENSDARG00000074510 1 Normal 24
si:busm1-160c18.3 HLA-DQB1 ENSDARG00000053738 None Not determined 24
si:busm1-160c18.3 HLA-DQB1 ENSDARG00000093706 None Not determined 24
si:busm1-194e12.12 HLA-DQB1 ENSDARG00000055447 None Not determined 24
si:busm1-228j01.4 HLA-DQB1 ENSDARG00000088872 2 Not determined 24
si:busm1-228j01.6 HLA-DQB1 ENSDARG00000041705 1 Not determined 24
si:ch211-287j19.6 MICB ENSDARG00000001470 2 Not determined 7
si:ch73-213j4.4 MICB ENSDARG00000092731 None Not determined 7
si:ch73-60e21.3 LRP1 ENSDARG00000029146 12 Not determined 6
si:dkey-27b3.5 ITGA1 ENSDARG00000074316 6 Not determined 5
si:dkey-6e12.6 CFDP1 ENSDARG00000095086 3 Not determined 2
si:zfos-2070c2.3 HLA-DQB1 ENSDARG00000076307 None Not determined 24
tgfb2 TGFB2 ENSDARG00000027087 None Not determined 2
TRIM71 TRIM71 ENSDARG00000075593 2 Not determined 1
wu:fd58b11 HLA-DQB1 ENSDARG00000054921 None Not determined 24
wwox WWOX ENSDARG00000007614 4 Not determined 9
zgc:109984 PPP1R14C ENSDARG00000054817 None Not determined 1
zgc:136614 MICB ENSDARG00000069471 None Not determined 7
zgc:153067 HLA-DQB1 ENSDARG00000056330 2 Not determined 24
zgc:64115 MICB ENSDARG00000036588 4 Not determined 7

The following reported genes could not be linked automatically to a zebrafish gene:

  • AK026189
  • CCDC38
  • KCNE2
  • NCR3
  • OR12D2
  • RARB
  • SPATA9
  • TET2
  • ZKSCAN3
  • ZNF323
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