GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
abcg2a ABCG2 ENSDARG00000043037 1 Not determined 10
abcg2b ABCG2 ENSDARG00000079361 None Not determined 10
abcg2c ABCG2 ENSDARG00000058574 3 Not determined 10
abcg2d ABCG2 ENSDARG00000016818 1 Not determined 10
apob APOB ENSDARG00000042780 9 Not determined 17
apobl APOB ENSDARG00000022767 11 Not determined 17
celsr1a CELSR2 ENSDARG00000069185 8 Not determined 17
CELSR2 CELSR2 ENSDARG00000088231 4 Not determined 17
celsr2l CELSR2 ENSDARG00000019726 2 Not determined 17
cetp CETP ENSDARG00000030872 2 Not determined 27
ldlr LDLR ENSDARG00000029476 3 Not determined 15
LDLR (2 of 2) LDLR ENSDARG00000089730 None Not determined 15
lipc LIPC ENSDARG00000053476 2 Not determined 24
LIPC (2 of 2) LIPC ENSDARG00000090486 None Not determined 24
LOC100331214 LPL ENSDARG00000034667 None Not determined 21
LOC100333044 GCKR ENSDARG00000086620 None Not determined 39
LOC100334697 BCHE ENSDARG00000053709 1 Not determined 5
lpl LPL ENSDARG00000087697 1 Not determined 21
LPL (1 of 2) LPL ENSDARG00000091659 2 Not determined 21
mhc1uba HFE ENSDARG00000075963 None Not determined 20
mhc1ze HFE ENSDARG00000074765 None Not determined 20
mhc1zel HFE ENSDARG00000092162 1 Not determined 20
mrc1a MRC1 ENSDARG00000073928 5 Not determined 1
mrc1b MRC1 ENSDARG00000038822 3 Not determined 1
NP_919406.1 HFE ENSDARG00000086877 1 Not determined 20
pcsk7 PCSK7 ENSDARG00000069968 None Not determined 2
Q8MHB3_DANRE HFE ENSDARG00000076734 None Not determined 20
Q8MHB6_DANRE HFE ENSDARG00000088022 1 Not determined 20
si:ch211-287j19.6 HFE ENSDARG00000001470 2 Not determined 20
si:ch211-71n6.4 BCHE ENSDARG00000088003 None Not determined 5
si:ch73-213j4.4 HFE ENSDARG00000092731 None Not determined 20
si:dkey-258f14.3 LDLR ENSDARG00000075974 None Not determined 15
si:dkey-30c15.17 BCHE ENSDARG00000058492 1 Normal 5
si:dkey-30k22.7 CELSR2 ENSDARG00000037286 4 Not determined 17
si:dkeyp-106c3.3 APOB ENSDARG00000093159 None Not determined 17
si:dkeyp-88f5.1 APOB ENSDARG00000075016 5 Not determined 17
tomm40 TOMM40 ENSDARG00000092112 1 Not determined 23
tomm40l TOMM40 ENSDARG00000036721 None Not determined 23
WDR1 WDR1 ENSDARG00000077991 2 Not determined 4
zgc:136614 HFE ENSDARG00000069471 None Not determined 20
zgc:64115 HFE ENSDARG00000036588 4 Not determined 20

The following reported genes could not be linked automatically to a zebrafish gene:

  • OASL
  • SLC17A4
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