GWAS

(GWAS data used on the Zebrafish Mutation Project Web site comes from http://www.genome.gov/gwastudies/.)

Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.

The human homologues of the following genes have been identified in this study:

Gene name Reported Gene Ensembl ID Alleles found Associated phenotype Study Count
abcg2a ABCG2 ENSDARG00000043037 None Not determined 10
abcg2b ABCG2 ENSDARG00000079361 None Not determined 10
abcg2c ABCG2 ENSDARG00000058574 3 Not determined 10
abcg2d ABCG2 ENSDARG00000016818 1 Not determined 10
apob APOB ENSDARG00000042780 7 Not determined 17
apobl APOB ENSDARG00000022767 6 Not determined 17
celsr1a CELSR2 ENSDARG00000069185 3 Not determined 17
CELSR2 CELSR2 ENSDARG00000088231 3 Not determined 17
celsr2l CELSR2 ENSDARG00000019726 1 Not determined 17
cetp CETP ENSDARG00000030872 1 Not determined 27
ldlr LDLR ENSDARG00000029476 1 Not determined 15
LDLR (2 of 2) LDLR ENSDARG00000089730 None Not determined 15
lipc LIPC ENSDARG00000053476 2 Not determined 24
LIPC (2 of 2) LIPC ENSDARG00000090486 None Not determined 24
LOC100331214 LPL ENSDARG00000034667 None Not determined 21
LOC100333044 GCKR ENSDARG00000086620 None Not determined 39
LOC100334697 BCHE ENSDARG00000053709 None Not determined 5
lpl LPL ENSDARG00000087697 1 Not determined 21
LPL (1 of 2) LPL ENSDARG00000091659 None Not determined 21
mhc1uba HFE ENSDARG00000075963 None Not determined 20
mhc1ze HFE ENSDARG00000074765 None Not determined 20
mhc1zel HFE ENSDARG00000092162 1 Not determined 20
mrc1a MRC1 ENSDARG00000073928 6 Not determined 1
mrc1b MRC1 ENSDARG00000038822 3 Not determined 1
NP_919406.1 HFE ENSDARG00000086877 2 Not determined 20
pcsk7 PCSK7 ENSDARG00000069968 None Not determined 2
Q8MHB3_DANRE HFE ENSDARG00000076734 None Not determined 20
Q8MHB6_DANRE HFE ENSDARG00000088022 None Not determined 20
si:ch211-287j19.6 HFE ENSDARG00000001470 1 Not determined 20
si:ch211-71n6.4 BCHE ENSDARG00000088003 None Not determined 5
si:ch73-213j4.4 HFE ENSDARG00000092731 None Not determined 20
si:dkey-258f14.3 LDLR ENSDARG00000075974 None Not determined 15
si:dkey-30c15.17 BCHE ENSDARG00000058492 1 Normal 5
si:dkey-30k22.7 CELSR2 ENSDARG00000037286 3 Not determined 17
si:dkeyp-106c3.3 APOB ENSDARG00000093159 None Not determined 17
si:dkeyp-88f5.1 APOB ENSDARG00000075016 3 Not determined 17
tomm40 TOMM40 ENSDARG00000092112 1 Not determined 23
tomm40l TOMM40 ENSDARG00000036721 None Not determined 23
WDR1 WDR1 ENSDARG00000077991 2 Not determined 4
zgc:136614 HFE ENSDARG00000069471 None Not determined 20
zgc:64115 HFE ENSDARG00000036588 2 Not determined 20

The following reported genes could not be linked automatically to a zebrafish gene:

  • OASL
  • SLC17A4
* quick link - http://q.sanger.ac.uk/z3lx1c70